Actively Recruiting
Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults
Led by University of Glasgow · Updated on 2026-04-24
64
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
Sponsors
U
University of Glasgow
Lead Sponsor
D
Dr Dalia Malkova
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will investigate how adding a specific type of dietary fat to daily meals for two weeks affects the gut bacteria and their activity. Participants will be randomly assigned to consume one of four types of fat: butter, coconut oil, olive oil, or sunflower oil (60 mL each day for 2 weeks). Stool and blood samples (after an overnight fast) will be collected at 3 time points during the study (Days 1, 7, and 22). These samples will be used to measure metabolites produced by gut bacteria, the types of bacteria present in the gut, blood lipids, and inflammatory markers. The study, based on previous in vitro findings, aims to understand whether different types of fats (based on their structure and level of saturation) have different effects on gut bacteria and their activity in healthy subjects.
CONDITIONS
Official Title
Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 20-50 years
- Body mass index (BMI) between 20 and 30 kg/m8
- Generally healthy
- Stable body weight (�b12 kg) over the past 2 months
- Living in the Glasgow area
- Non-smoker
You will not qualify if you...
- Use of antibiotics within the past 3 months
- Current use of medications affecting gut microbiota or cardiometabolic health
- Regular use of dietary supplements that may influence study outcomes unless willing to discontinue prior to study start
- Presence of chronic gastrointestinal, metabolic, cardiovascular, hepatobiliary, or pancreatic disease
- History of major gastrointestinal surgery
- Diagnosed diabetes or use of lipid-lowering therapy
- Known fat malabsorption disorders
- Pregnant or lactating women
- Post-menopausal women
- Following a restrictive or specific diet such as vegan or ketogenic
- Food allergies or intolerances relevant to study fats such as dairy or coconut
- Recent significant weight change (�b12 kg in the past month)
- High reliance on ready meals or takeaway foods (more than 7 main meals per week)
- Participation in another research study that may interfere with this study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, G31 2ER
Glasgow, United Kingdom, G31 2ER
Actively Recruiting
Research Team
L
Linah Alhomidan
CONTACT
A
Athanasios Koutsos
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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