Comparison of volume-controlled ventilation mode and pressure-controlled ventilation with volume-guaranteed mode in the prone position during lumbar spine surgery.
Jung Min Lee, Soo Kyung Lee, Kyung Mi Kim...
https://pubmed.ncbi.nlm.nih.gov/31351445Actively Recruiting
Led by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Updated on 2026-04-08
60
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating whether applying alveolar recruitment maneuvers (ARM) periodically during elective spine surgery in the prone position can reduce lung collapse (atelectasis) and improve breathing mechanics under general anesthesia. This randomized controlled trial involves adult patients undergoing spine surgery lasting at least two hours. The study compares a routine single-time ARM with periodic ARM to see if repeated maneuvers better maintain lung aeration and respiratory function during surgery. Participants are randomly assigned to one of two groups. Both receive standard general anesthesia and ventilation, with a baseline ARM after positioning. The periodic ARM group receives additional recruitment maneuvers approximately once per hour during surgery plus a final ARM before extubation. The standard ARM group receives only the baseline and final ARM. All maneuvers are performed within established safety limits without introducing experimental drugs or devices. During the study, lung aeration is assessed using lung ultrasound at multiple time points, including before extubation. Researchers also monitor respiratory mechanics such as airway pressures, lung compliance, oxygen levels, and any transient respiratory or blood flow changes. The main outcome is the incidence of intraoperative atelectasis before extubation. Monitoring continues into the recovery period to evaluate oxygen levels and lung aeration. The total participation duration depends on surgery and immediate recovery phases.
CONDITIONS
Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgical procedure lasting at least 2 hours
Participants undergo elective spine surgery in the prone position under general anesthesia. After prone positioning, a baseline alveolar recruitment maneuver is performed. Participants in the periodic recruitment group receive additional recruitment maneuvers approximately once per hour during surgery. A final recruitment maneuver is performed before extubation as part of routine anesthetic care. Respiratory parameters and lung aeration are assessed intraoperatively using lung ultrasound and respiratory monitoring.
1 intraoperative period with assessments at baseline, hourly intervals, and immediately before extubation
Duration - Up to 30 minutes after surgery
Participants are monitored in the post-anesthesia care unit where lung ultrasound and respiratory parameters continue to be assessed up to 30 minutes after arrival.
1 post-operative visit (in-person)
Total: 1 location
1
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Istanbul, Turkey (Türkiye)
Actively Recruiting
S
Serap KARACALAR, MD (Doctor of Medicine)
S
Serencan OZER, MD (Doctor of Medicine)
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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