Actively Recruiting

Phase Not Applicable
Age: 18Years - 65Years
All Genders
ID07325812

Evaluation of the Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics in Elective Spine Surgery Using Lung Ultrasonography

Led by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Updated on 2026-04-08

60

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating whether applying alveolar recruitment maneuvers (ARM) periodically during elective spine surgery in the prone position can reduce lung collapse (atelectasis) and improve breathing mechanics under general anesthesia. This randomized controlled trial involves adult patients undergoing spine surgery lasting at least two hours. The study compares a routine single-time ARM with periodic ARM to see if repeated maneuvers better maintain lung aeration and respiratory function during surgery. Participants are randomly assigned to one of two groups. Both receive standard general anesthesia and ventilation, with a baseline ARM after positioning. The periodic ARM group receives additional recruitment maneuvers approximately once per hour during surgery plus a final ARM before extubation. The standard ARM group receives only the baseline and final ARM. All maneuvers are performed within established safety limits without introducing experimental drugs or devices. During the study, lung aeration is assessed using lung ultrasound at multiple time points, including before extubation. Researchers also monitor respiratory mechanics such as airway pressures, lung compliance, oxygen levels, and any transient respiratory or blood flow changes. The main outcome is the incidence of intraoperative atelectasis before extubation. Monitoring continues into the recovery period to evaluate oxygen levels and lung aeration. The total participation duration depends on surgery and immediate recovery phases.

CONDITIONS

Brief Title

Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography

Who Can Participate

Age: 18Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 to 65 years
  • Scheduled for elective lumbar spine surgery under general anesthesia
  • Surgery planned to be performed in the prone position
  • Expected surgical duration of at least 2 hours
  • American Society of Anesthesiologists (ASA) physical status I-II
  • Ability to provide written informed consent
Not Eligible

You will not qualify if you...

  • Body mass index (BMI) greater than 30 kg/m²
  • History of thoracic surgery
  • Known or suspected chronic pulmonary disease such as chronic obstructive or restrictive lung disease
  • Clinically significant cardiac disease
  • Pregnancy or breastfeeding
  • Known airway anomalies
  • Intraoperative surgical duration shorter than 2 hours
  • Refusal or inability to provide informed consent

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Surgical procedure lasting at least 2 hours

Participants undergo elective spine surgery in the prone position under general anesthesia. After prone positioning, a baseline alveolar recruitment maneuver is performed. Participants in the periodic recruitment group receive additional recruitment maneuvers approximately once per hour during surgery. A final recruitment maneuver is performed before extubation as part of routine anesthetic care. Respiratory parameters and lung aeration are assessed intraoperatively using lung ultrasound and respiratory monitoring.

1 intraoperative period with assessments at baseline, hourly intervals, and immediately before extubation

Post-operative Follow-up

Duration - Up to 30 minutes after surgery

Participants are monitored in the post-anesthesia care unit where lung ultrasound and respiratory parameters continue to be assessed up to 30 minutes after arrival.

1 post-operative visit (in-person)

Trial Site Locations

Total: 1 location

1

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Istanbul, Turkey (Türkiye)

Actively Recruiting

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Research Team

S

Serap KARACALAR, MD (Doctor of Medicine)

S

Serencan OZER, MD (Doctor of Medicine)

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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Published Research Related To This Trial

Comparison of volume-controlled ventilation mode and pressure-controlled ventilation with volume-guaranteed mode in the prone position during lumbar spine surgery.

Jung Min Lee, Soo Kyung Lee, Kyung Mi Kim...

https://pubmed.ncbi.nlm.nih.gov/31351445

Comparison of pressure controlled, volume controlled, and volume guaranteed pressure controlled modes in prone position in patients operated for lumbar disc herniation: A randomized trial.

Ferim Sakize Gunenc, İlkana Seyidova, Sule Ozbilgin...

https://pubmed.ncbi.nlm.nih.gov/38335373

Effect of regular alveolar recruitment on intraoperative atelectasis in paediatric patients ventilated in the prone position: a randomised controlled trial.

Young-Eun Jang, Sang-Hwan Ji, Eun-Hee Kim...

https://pubmed.ncbi.nlm.nih.gov/32169254

Intraoperative protective mechanical ventilation for prevention of postoperative pulmonary complications: a comprehensive review of the role of tidal volume, positive end-expiratory pressure, and lung recruitment maneuvers.

Andreas Güldner, Thomas Kiss, Ary Serpa Neto...

https://pubmed.ncbi.nlm.nih.gov/26120769