Comparing Remifentanil, Fentanyl, and N2O to Prevent Agitation After Nasal Surgery with Desflurane Anesthesia

What this Trial Is About

This research aims to evaluate how well remifentanil works in preventing emergence agitation compared to fentanyl and nitrous oxide in patients undergoing rhinoplasty with desflurane anesthesia. The study also examines differences in patient demographics, intraoperative and postoperative heart and blood pressure data, surgical time, and recovery scores among the different analgesia methods. This is a prospective, randomized, double-blind trial conducted to better understand pain management during nasal surgery. Participants are randomly assigned to one of three groups Group 1 receives an intravenous infusion of remifentanil at 0.05-0.2 micrograms per kilogram per minute Group 2 receives nitrous oxide for analgesia Group 3 receives desflurane with oxygen and air plus an intravenous bolus of fentanyl at 1 microgram per kilogram if heart rate or blood pressure increases by 20% during surgery. These treatments are given during the operation under general anesthesia. During the study, researchers will assess agitation and sedation levels using the Richmond Agitation-Sedation Scale at 1, 5, and 15 seconds in the postoperative care unit. They will also monitor mean arterial pressure and heart rate before induction and at multiple time points after intubation. Participants will be observed for surgical and recovery data, with safety and effectiveness measures recorded throughout. The total participation period covers the surgery and immediate recovery phase.

Efficacy of Remifentanil in Preventing Emergence Agitation