Screening Adults Aged 30 and Older Without Stomach Symptoms for Helicobacter Pylori and Early Stomach Changes During Colonoscopy

What this Trial Is About

This research aims to determine how common Helicobacter pylori infection is among adults aged 30 years and older who show no symptoms in their stomach or upper digestive tract and are undergoing a preventive screening colonoscopy. The study also investigates potential links between this infection and other risk factors such as body weight, smoking habits, alcohol use, and family history of colorectal or stomach cancer. By studying these relationships, researchers hope to better understand early tissue changes that could lead to stomach cancer. Participants will be offered an additional gastroscopy, a procedure to examine the stomach lining, during their routine colonoscopy session. Small tissue samples will be collected from the stomach and lower esophagus to check for the presence of Helicobacter pylori and early tissue changes like intestinal metaplasia and Barretts mucosa. This extra gastroscopy follows the standard steps of a routine examination and does not involve additional procedures beyond those normally performed. During the study, participant privacy is protected by coding all collected data. Researchers will analyze biopsy results and other health information using statistical methods over a 7-day observation period from enrollment. The main measure is how many asymptomatic patients test positive for Helicobacter pylori, and secondary measures include the detection of intestinal metaplasia or Barretts mucosa. About 1000 adults are expected to participate, with no upper age limit specified.

Endoscopic Screening of Asymptomatic Patients for Helicobacter Pylori, Intestinal Metaplasia, and Barrett's Mucosa During Screening Colonoscopy