Actively Recruiting
Endoscopic Screening of Asymptomatic Adults for Helicobacter Pylori, Intestinal Metaplasia, and Barrett's Mucosa During Screening Colonoscopy
Led by Sigmund Freud PrivatUniversitat · Updated on 2026-03-09
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to determine how common Helicobacter pylori infection is among adults aged 30 years and older who show no symptoms in their stomach or upper digestive tract and are undergoing a preventive screening colonoscopy. The study also investigates potential links between this infection and other risk factors such as body weight, smoking habits, alcohol use, and family history of colorectal or stomach cancer. By studying these relationships, researchers hope to better understand early tissue changes that could lead to stomach cancer. Participants will be offered an additional gastroscopy, a procedure to examine the stomach lining, during their routine colonoscopy session. Small tissue samples will be collected from the stomach and lower esophagus to check for the presence of Helicobacter pylori and early tissue changes like intestinal metaplasia and Barrett's mucosa. This extra gastroscopy follows the standard steps of a routine examination and does not involve additional procedures beyond those normally performed. During the study, participant privacy is protected by coding all collected data. Researchers will analyze biopsy results and other health information using statistical methods over a 7-day observation period from enrollment. The main measure is how many asymptomatic patients test positive for Helicobacter pylori, and secondary measures include the detection of intestinal metaplasia or Barrett's mucosa. About 1000 adults are expected to participate, with no upper age limit specified.
CONDITIONS
Brief Title
Endoscopic Screening of Asymptomatic Patients for Helicobacter Pylori, Intestinal Metaplasia, and Barrett's Mucosa During Screening Colonoscopy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �30 years or older
- Scheduled for a screening colonoscopy (initial or follow-up after polyps)
- No gastrointestinal symptoms
- Willing to undergo gastroscopy with biopsy during colonoscopy
- Provided written informed consent for study participation and data use
You will not qualify if you...
- Known Helicobacter pylori infection or previous treatment
- Current or recent proton pump inhibitor therapy within 4 weeks
- Pre-existing gastrointestinal diseases such as chronic gastritis, ulcer, or gastric cancer
- Immunosuppression or significant underlying diseases
- Refusal to have additional gastroscopy or biopsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo synchronous gastroscopy with biopsy during their scheduled screening colonoscopy to detect Helicobacter pylori infection and assess for intestinal metaplasia and Barrett's mucosa.
1 combined gastroscopy and colonoscopy visit
Duration - 7 days
Participants are observed for outcomes related to Helicobacter pylori infection and tissue changes for up to 7 days after the procedure.
Follow-up observation with no additional visits required
Trial Site Locations
Total: 1 location
1
Wiener Privatklinik (WPK)
Vienna, Austria, 1090
Actively Recruiting
Research Team
H
Harald Rosen, Univ. Prof. Dr.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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