Actively Recruiting
Engage: A Treatment for Late-Life Depression and Comorbid Executive/Cognitive Dysfunction
Led by University of Nevada, Las Vegas · Updated on 2024-08-06
20
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the Engage behavioral treatment approach for older adults aged 60 and above who experience late-life depression along with cognitive decline, including executive dysfunction and mild cognitive impairment. The study aims to confirm whether Engage is a feasible and suitable alternative treatment for this group, addressing the challenge that cognitive decline poses to traditional mental health therapies in older populations. Participants will undergo a single-arm 9-week Engage therapy protocol designed specifically for late-life depression combined with cognitive difficulties. This behavioral psychotherapy is delivered weekly and focuses on improving depression symptoms despite cognitive challenges. The study does not include a comparison group but monitors the response to this intervention over time. During the study, participants will be assessed using several measures including the Hamilton Depression Rating Scale, the World Health Organization Disability Assessment Schedule 2.0, the Behavioral Activation for Depression Scale, and the Social Problem-Solving Inventory Revised-Short Form. These evaluations take place at baseline, weeks 6 and 9 during treatment, and at a follow-up visit at week 36. The study is sponsored by the University of Nevada, Las Vegas, and involves regular visits where participants' mood, disability, behavior activation, and problem-solving abilities are tracked to understand treatment feasibility and effects.
CONDITIONS
Brief Title
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 or older
- Ability to read, write, and speak English
- Located in Las Vegas or surrounding area
- Ability to travel to UNLV campus by self or possible caregiver for regular study visits
- Clinically significant symptoms of depression as shown by a Geriatric Depression Scale-Short Form score greater than 5
- Mild cognitive impairment with Montreal Cognitive Assessment scores between 19 and 24
You will not qualify if you...
- Active suicidal thoughts
- History of suicide attempts
- Current psychosis or active substance use disorder
- History of bipolar disorder or intellectual disability
- Currently in or planning to start individual psychotherapy
- Psychotropic medication dose not stable for at least 2 weeks
- Living in an institutional setting such as assisted living or skilled nursing
- Significant memory deficits with MoCA memory subscale scores below 9 that impair participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 9 weeks
Participants receive a 9-week behavioral-based psychotherapy treatment called Engage for late-life depression and comorbid executive dysfunction.
Weekly visits for 9 weeks
Duration - 27 weeks
Participants are followed up to assess outcomes after completing treatment.
1 visit at Week 36 follow-up
Trial Site Locations
Total: 1 location
1
University of Nevada
Las Vegas, Nevada, United States, 89154
Actively Recruiting
Research Team
B
Brenna R Renn, PhD
M
Matthew S Schurr, MA
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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