Optimizing a Digital Meditation Program to Improve Attention and Reduce Stress in Older Adults with Cognitive Decline

What this Trial Is About

Researchers are evaluating a digital meditation intervention aimed at improving attention, cognitive function, and wellbeing in older adults experiencing cognitive decline or mild cognitive impairment MCI. The study also examines how factors like cognitive decline level, genetic risk for Alzheimers disease, cardiovascular risk, and race or ethnicity might influence treatment effects. This research seeks to develop a personalized approach to cognitive enhancement for individuals at risk of dementia. Participants will be randomly assigned to one of several groups using a tablet-based meditation-inspired cognitive training game called MediTrain, which adapts in difficulty as users improve. Different groups will use the app for varying durations and session lengths 15 or 30 minutes per day for 3 or 6 weeks. There is also an active control group using a different app designed to match expectations of benefit but without the same cognitive training focus. During the study, participants will complete cognitive assessments at baseline, immediately after training, and at a 6-month follow-up. These include the Mobile Continuous Performance Task CPT and the Adaptive Cognitive Evaluation ACE, which measure attention and cognitive abilities over time. Researchers will monitor engagement with the digital app and track changes in cognitive performance to assess the interventions impact. The study is expected to continue until June 2029.

Enhancing Attention and Wellbeing Using Digital Therapeutics