Actively Recruiting
Optimizing a Closed-loop Digital Meditation Intervention for Remediating Cognitive Decline and Reducing Stress in Older Adults
Led by University of California, San Francisco · Updated on 2026-02-24
4000
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a digital meditation intervention aimed at improving attention, cognitive function, and wellbeing in older adults experiencing cognitive decline or mild cognitive impairment (MCI). The study also examines how factors like cognitive decline level, genetic risk for Alzheimer's disease, cardiovascular risk, and race or ethnicity might influence treatment effects. This research seeks to develop a personalized approach to cognitive enhancement for individuals at risk of dementia. Participants will be randomly assigned to one of several groups using a tablet-based meditation-inspired cognitive training game called MediTrain, which adapts in difficulty as users improve. Different groups will use the app for varying durations and session lengths (15 or 30 minutes per day for 3 or 6 weeks). There is also an active control group using a different app designed to match expectations of benefit but without the same cognitive training focus. During the study, participants will complete cognitive assessments at baseline, immediately after training, and at a 6-month follow-up. These include the Mobile Continuous Performance Task (CPT) and the Adaptive Cognitive Evaluation (ACE), which measure attention and cognitive abilities over time. Researchers will monitor engagement with the digital app and track changes in cognitive performance to assess the intervention's impact. The study is expected to continue until June 2029.
CONDITIONS
Brief Title
Enhancing Attention and Wellbeing Using Digital Therapeutics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 60 years of age or older
- Fluent in English
- Own a smartphone or tablet device
You will not qualify if you...
- Under 60 years of age
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 3 to 6 weeks
Participants engage with a digital meditation app or an active control application for cognitive training.
Daily sessions 15 to 30 minutes per day, 5 days per week
Duration - 6 months
Participants complete assessments to measure changes in cognitive performance immediately after training and again at 6 months.
2 follow-up visits (immediate and 6 months)
Trial Site Locations
Total: 1 location
1
University of California San Francisco
San Francisco, California, United States, 94158
Actively Recruiting
Research Team
D
David Ziegler, PhD
M
Monique de Villa, MS, MPH
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
5
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