Observational Study of Cluster Headache and Trigeminal Neuralgia by the Will Erwin Headache Research Center

What this Trial Is About

Researchers are conducting a national, prospective, multicenter observational study at the Will Erwin Headache Research Center focused on patients with Cluster Headache and Trigeminal Neuralgia. This study also includes similar conditions such as other trigeminal autonomic cephalalgias TACs like paroxysmal hemicrania, SUNCT, SUNA, and hemicrania continua. The goal is to create a detailed registry that categorizes patients by condition type, severity, symptoms, and related medical or psychological issues including depression and disability. Participants include patients diagnosed with these headache disorders as well as healthy volunteer controls and family members, who may be enrolled to help identify genetic mutations. Each enrolled participant undergoes comprehensive evaluations including genomic and epigenomic studies, collection of past medical history, imaging reports, and physical exams. This registry aims to support matching patients with appropriate interventional clinical trials in the future. During the study, participants will be assessed with several scales including the HIT-6 for headache impact, the morningness-eveningness scale, and the GAD-7 for anxiety, all over an average of five years. Genetic and molecular biomarkers will also be collected and monitored throughout this period. This long-term observational study continues through its completion, providing ongoing data on the studied conditions and patient characteristics.

The Will Erwin Headache Research Center - Cluster Headache Study