The International Classification of Headache Disorders, 3rd edition (beta version).
Headache Classification Committee of the International Headache Society (IHS)
https://pubmed.ncbi.nlm.nih.gov/23771276Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID02910323
The Will Erwin Headache Research Center Study of Cluster Headache and Trigeminal Neuralgia
Led by The University of Texas Health Science Center, Houston · Updated on 2026-02-18
1500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a national, prospective, multicenter observational study at the Will Erwin Headache Research Center focused on patients with Cluster Headache and Trigeminal Neuralgia. This study also includes similar conditions such as other trigeminal autonomic cephalalgias (TACs) like paroxysmal hemicrania, SUNCT, SUNA, and hemicrania continua. The goal is to create a detailed registry that categorizes patients by condition type, severity, symptoms, and related medical or psychological issues including depression and disability. Participants include patients diagnosed with these headache disorders as well as healthy volunteer controls and family members, who may be enrolled to help identify genetic mutations. Each enrolled participant undergoes comprehensive evaluations including genomic and epigenomic studies, collection of past medical history, imaging reports, and physical exams. This registry aims to support matching patients with appropriate interventional clinical trials in the future. During the study, participants will be assessed with several scales including the HIT-6 for headache impact, the morningness-eveningness scale, and the GAD-7 for anxiety, all over an average of five years. Genetic and molecular biomarkers will also be collected and monitored throughout this period. This long-term observational study continues through its completion, providing ongoing data on the studied conditions and patient characteristics.
CONDITIONS
Brief Title
The Will Erwin Headache Research Center - Cluster Headache Study
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Diagnosis of trigeminal autonomic cephalalgia or trigeminal neuralgia as defined by the International Headache Classification, including various episodic and chronic forms
- Ability to provide HIPAA authorization to share prior medical records and imaging
- Healthy volunteers aged 18 or older willing to consent
You will not qualify if you...
- Life expectancy less than 1 year or other conditions preventing proper diagnosis
- Active drug or alcohol use or dependence interfering with study adherence
- Inability or unwillingness to provide informed consent or have a legal guardian provide it
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Initial assessment period
Participants undergo detailed evaluations including genomic and epigenomic studies, past medical history review, imaging reports, and physical exams to classify their condition.
1 to 2 visits depending on assessments
Long-term Monitoring
Duration - Approximately 5 years
Participants are followed over time with assessments using various scales and biomarker measurements to observe their condition.
Periodic visits for assessments throughout the study duration
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
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Research Team
R
Rebecca Martinez, RN
M
Mark J Burish, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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