The estrogen replacement and atherosclerosis (ERA) study: study design and baseline characteristics of the cohort.
D M Herrington, D M Reboussin, K P Klein...
https://pubmed.ncbi.nlm.nih.gov/10822123Completed
Phase 3
Age: 45Years - 75Years
FEMALE
ID00000549
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-03-16
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To determine if estrogen replacement therapy, with or without low dose progesterone, slows progression or induces regression of coronary atherosclerosis in postmenopausal women.
CONDITIONS
Official Title
Estrogen Replacement and Atherosclerosis (ERA) in Older Women
Who Can Participate
Age: 45Years - 75Years
FEMALE
Eligibility Criteria
You may qualify if you...
Postmenopausal women with established coronary atherosclerosis.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
PREVENTION
Number of Arms
0
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Published Research Related To This Trial
Recruitment of participants for the Estrogen Replacement and Atherosclerosis (ERA) trial. a comparison of costs, yields, and participant characteristics from community- and hospital-based recruitment strategies.
S Folmar, F Oates-Williams, P Sharp...
https://pubmed.ncbi.nlm.nih.gov/11165419Effects of estrogen replacement on the progression of coronary-artery atherosclerosis.
D M Herrington, D M Reboussin, K B Brosnihan...
https://pubmed.ncbi.nlm.nih.gov/10954759Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease.
Arja T Erkkilä, Alice H Lichtenstein, Dariush Mozaffarian...
https://pubmed.ncbi.nlm.nih.gov/15321802Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease.
David M Herrington, Timothy D Howard, Gregory A Hawkins...
https://pubmed.ncbi.nlm.nih.gov/11919305Hormone therapy, C-reactive protein, and progression of atherosclerosis: data from the Estrogen Replacement on Progression of Coronary Artery Atherosclerosis (ERA) trial.
Susan G Lakoski, Bridget Brosnihan, David M Herrington
https://pubmed.ncbi.nlm.nih.gov/16290959