Observational Study Evaluating the Argos System for Monitoring Cardiac Output Changes in Critically Ill Patients with Shock

What this Trial Is About

Researchers are evaluating the Argos systems ability to monitor changes in cardiac output in critically ill patients experiencing shock. This observational study compares the Argos system with the transpulmonary thermodilution TPTD method, which is considered a reliable but invasive standard for cardiac output measurement in patients with acute circulatory failure. The study focuses on determining whether the Argos system can accurately track cardiac output changes caused by fluid administration or changes in norepinephrine dosage. The study involves patients already monitored with the transpulmonary thermodilution device and experiencing shock indicated by signs of poor blood flow. Participants undergo hemodynamic interventions including a 500mL fluid bolus of normal saline and brief adjustments in norepinephrine to raise mean arterial pressure by 15mmHg. The Argos monitor analyzes arterial pressure waveforms without additional sensors and provides cardiac output estimates during these interventions. The study compares cardiac output changes measured by the Argos system to those measured by the TPTD device. Participants are hospitalized in intensive care units with hemodynamic monitoring already in place. Researchers collect cardiac output data before and after fluid or norepinephrine interventions over approximately one hour. The study measures accuracy and precision of the Argos system in tracking cardiac output changes. No invasive procedures beyond routine care are added, and the total participation duration corresponds with medical interventions and monitoring during intensive care stay.

Evaluation of the Argos System to Estimate Cardiac Output