Evaluation of the Elasticity of the Mitral Valve Chordae by Uniaxial Traction in Patients with Mitral Valve Regurgitation Comparing Mitral Valve Prolapse and Restriction of Mitral Valve Movement

What this Trial Is About

Researchers are studying the mechanobiological and histological properties of mitral valve chords in living humans, focusing on differences in elasticity between patients with mitral valve prolapse and those with restrictive ischemic mitral valve. This observational study addresses a gap in existing research, which primarily involves animal tissues or non-living human samples. The goal is to better understand mitral valve regurgitation through direct examination of living human tissue. The study will include 20 patients undergoing mitral valve replacement, selected consecutively without randomization. Tissue samples will be harvested during surgery and preserved in natural conditions without freezing to maintain their properties. Two groups are compared: one with mitral valve prolapse and the other with restrictive ischemic mitral valve movement. Data collection will include patient medical history and intraoperative results. Participants will be involved during their scheduled valve replacement surgery, when tissue samples are taken and analyzed. Researchers will measure the maximum value of Young's modulus to assess elasticity and perform initial histological evaluations of the tissue. The study aims to gather detailed mechanical and structural information on mitral valve chords, contributing to improved understanding of mitral valve disease. The total participation duration aligns with the surgical and data collection process.

Evaluation of the Elasticity of the Mitral Valve