What this Trial Is About

Researchers are investigating the mechanobiological and histological properties of the mitral valve chords in living humans, focusing on patients with mitral valve prolapse compared to those with ischemic mitral valve restriction. This study addresses a gap in literature where previous examinations were limited to animal tissues, cadavers, or frozen human samples. The study will include 20 patients who are scheduled for mitral valve replacement and are over 45 years old. Tissue samples from the mitral valve chords will be collected and preserved in natural conditions without freezing. Researchers will collect data on patient history and intraoperative results to analyze and compare the elasticity of the mitral valve chords between the two patient groups. Participants will be involved through the collection of tissue samples during surgery and the monitoring of their clinical data. Researchers will measure the maximum value of Young's modulus in the mitral valve chords within the first hour. The study is prospective, with patients selected consecutively, and data will be carefully recorded to evaluate differences in tissue elasticity linked to mitral valve disease.

Evaluation of the Elasticity of the Mitral Valve