Actively Recruiting
MitrAl Valve Calcium aSsEssmEnt With TrueVue Trans-illumination 3D Rendering (MAC SEE).
Led by Centro Cardiologico Monzino · Updated on 2026-05-28
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying mitral valve calcifications, which are important to understand for planning heart surgery or catheter procedures. The study compares two imaging methods: contrast-enhanced computed tomography (CT), which is the gold standard for detecting calcium deposits, and three-dimensional transesophageal echocardiography using TrueVue transillumination, an advanced echocardiography technique that creates detailed, photorealistic images of the heart. The study includes two parts: a prospective part where adult patients scheduled for both CT and 3D transesophageal echocardiography as part of their routine care are enrolled, and a retrospective part reviewing existing data from patients who have already had both tests between February and September 2025. No extra diagnostic procedures or treatments will be given beyond usual care as this is an observational study. Participants will have their imaging data collected and analyzed to compare the accuracy of these two techniques in measuring mitral valve calcifications. The study will assess the amount and extent of calcium deposits on the mitral valve and aims to provide better evaluation tools. The study runs until June 2026 and does not include additional procedures beyond standard clinical assessments.
CONDITIONS
Brief Title
MitrAl Valve Calcium aSsEssmEnt With TrueVue Trans-illumination 3D Rendering.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Scheduled to undergo both contrast-enhanced CT scan and three-dimensional transesophageal echocardiography as part of routine clinical care
- Provided written informed consent to participate
- Have already undergone both contrast-enhanced CT scan and transesophageal echocardiogram between February 2025 and September 2025 (retrospective cohort)
You will not qualify if you...
- Patients younger than 18 years
- Patients with incomplete data for study assessments
- Patients who have refused use of their data for research purposes
- Patients who have not signed the informed consent form (prospective cohort)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or record review)
Duration - Up to 8 months depending on clinical scheduling
Participants undergo contrast-enhanced computed tomography (CT) and three-dimensional transesophageal echocardiography (3D TEE) as part of their routine clinical care. No additional procedures are performed.
1 to 2 visits depending on clinical care schedule
Duration - Up to the study completion date in June 2026
Data from completed diagnostic evaluations and clinical records are collected and analyzed without additional participant visits or procedures.
No additional visits
Trial Site Locations
Total: 1 location
1
Centro Cardiologico Monzino; IRCCS
Milan, Milan, Italy, 20138
Actively Recruiting
Research Team
G
Gianluca Pontone, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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