Study of Oral THC and CBD Effects on Blood Levels, Cognitive Function, and Oral Fluid Detection in Adults

What This Trial Is About

Researchers are studying the effects of oral delta-9-tetrahydrocannabinol THC and cannabidiol CBD in adults aged 21 to 55 who use cannabis occasionally. The study evaluates how these substances behave in the body, including how they affect blood levels, oral fluid detection, and cognitive performance. This research is a double-blind, placebo-controlled trial aiming to better understand THC and CBDs pharmacokinetics and pharmacodynamics. Participants receive different oral treatments including placebo oils, THC alone, CBD alone, or a combination of THC and CBD. Each treatment involves 20 mg doses of THC andor CBD suspended in sesame or MCT oil. The study uses a crossover design where each participant receives all treatments at different times in a randomized order. During the study, participants undergo blood and oral fluid testing to measure THC, CBD, metabolites, and recent use detection. Subjective effects and cognitive performance are assessed with behavioral tasks using the DRUID App over a 6-hour period after dosing. The research includes close monitoring of effects and safety, with all visits and procedures completed within the study timeframe.

Evaluation of Oral THC and CBD in Men and Women