Latent class analysis of bipolar disorder symptoms and suicidal ideation and behaviors.
Josephine S Au, Ana Martinez de Andino, Yara Mekawi...
https://pubmed.ncbi.nlm.nih.gov/32579284/Actively Recruiting
Led by Emory University · Updated on 2026-01-07
130
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are investigating the environmental and psychological factors that influence suicidal thoughts and behaviors in patients diagnosed with Bipolar Disorder. This study focuses on understanding why individuals with Bipolar Disorder have a high risk of suicide, exploring connections such as childhood maltreatment, impulsive aggression, and drug use. The research aims to improve suicide risk assessment and treatment, especially among low-income patients. Participants will take part in a 6-week group-based intervention program that includes therapies like Interpersonal and Social Rhythm Therapy, Bipolar-Specific Cognitive Behavioral Therapy, Mindfulness-Based Stress Reduction, and Psycho-education about Bipolar medications. Each therapy session lasts about 55-60 minutes and is conducted once a week in groups of 4 to 12 participants. During the study, participants will be evaluated using tools such as the Columbia-Suicide Severity Rating Scale before and after the intervention to measure changes in suicidal behavior. The study involves assessments of psychological and environmental factors, with the goal of reducing suicidal behaviors and improving quality of life. The total participation period is approximately six weeks, with monitoring focused on therapy effects and participant progress.
CONDITIONS
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
D
Dorian Lamis, PhD
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Emory University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Trial behavioral program | Adjunctive psychotherapy in bipolar disorder |
|---|---|---|
| What it is | A six‑week single‑group program combining Interpersonal and Social Rhythm Therapy, bipolar‑specific cognitive behavioral therapy, mindfulness‑based stress reduction and psycho‑education, delivered in weekly 55‑ to 60‑minute sessions | Psychotherapy such as IPSRT or CBT is commonly used alongside medication as an evidence‑based adjunct in bipolar disorder |
| Role in study | Investigational combination behavioral intervention tested on a single cohort | Represents standard psychotherapy approaches used as adjuncts in clinical practice, not tested in this trial |
| Primary use | To reduce suicidal ideation and behavior in people with bipolar disorder through multi‑component therapy | Used as adjunctive treatments to improve mood stability and reduce suicidal constructs in bipolar disorder |
| How it is delivered | Delivered weekly in‑person sessions of 55‑60 minutes over six weeks, combining multiple behavioral modalities | IPSRT or CBT typically delivered in weekly outpatient psychotherapy sessions alongside medication |
| Evidence status | Efficacy in this multi‑component format remains under evaluation; results not yet available | IPSRT has demonstrated reductions in suicidal ideation constructs in bipolar disorder when added to medication |
| Important risks | Not reported | Standard psychotherapy carries minimal risk; evidence does not report serious harms |
| Important limitations | Single‑group design without control limits ability to attribute effects solely to the combined intervention | Evidence for concrete suicide reduction largely limited to proxy indicators and adjunctive use, not as standalone interventions |
| Observed patient‑relevant outcomes | Not yet available | IPSRT adjuncts reduced key psychological constructs linked to suicide risk, such as perceived burdensomeness and suicidal ideation proxies |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 weeks
Participants receive group-based behavioral therapies including Interpersonal and Social Rhythm Therapy, Bipolar-Specific Cognitive Behavioral Therapy, Mindfulness-Based Stress Reduction, and Psycho-education & Understanding Bipolar Medications Therapy to reduce suicidal behavior and improve quality of life.
Weekly visits for therapy sessions
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Josephine S Au, Ana Martinez de Andino, Yara Mekawi...
https://pubmed.ncbi.nlm.nih.gov/32579284/Emory University
Lead Sponsor