Actively Recruiting
Evaluation of the Stability of Volatile Sulfur Compounds in Gas Samples for Halitosis Diagnosis
Led by University Hospital, Strasbourg, France · Updated on 2025-08-06
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Halitosis, or bad breath, affects about 30% of people worldwide, often caused by oral conditions like periodontitis. Diagnosing halitosis requires a clinical interview to distinguish real halitosis from psychological causes, along with measuring volatile sulfur compounds (VSC) in exhaled air. Since many healthcare facilities lack the equipment to measure VSCs, patients often travel far for this analysis. This study aims to evaluate how stable VSC values are in gas samples up to seven days after collection, to see if delayed analysis is clinically useful. Participants will provide gaseous samples by aspirating the air from their oral cavity using a 1ml plastic syringe. The study will analyze the concentration of hydrogen sulfide (H2S), a key VSC, at the time of sampling (Day 0) and again after seven days. This approach explores whether patients can collect samples at home and have them analyzed later, potentially simplifying diagnosis. During the study, participants will undergo sampling of exhaled air for VSC measurement at two time points. Researchers will compare the stability of H2S levels between Day 0 and Day 7. Participants must be adults seeking diagnosis or treatment for periodontal disease and able to consent. The study is sponsored by the University Hospital in Strasbourg, France, and does not involve treatment but focuses on diagnostic methods for halitosis.
CONDITIONS
Brief Title
Evaluation of the Stability of Sulfur Volatile Compounds From Exhaled Air for Halitosis Diagnosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult, male or female
- Subject affiliated with a social health insurance plan
- Able to understand the objectives and risks of the research and to give dated and signed informed consent
- Subject presenting for consultation for diagnosis and treatment of periodontal pathology
You will not qualify if you...
- Subject under safeguard of justice
- Subject under guardianship or curatorship
- Pregnancy or breast-feeding
- Impossibility of giving the subject informed information (subject in emergency situation, difficulties in understanding the subject, etc.)
- Subject currently included in another clinical research protocol or in an exclusion period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 7 days
Participants undergo gaseous sampling of their oral cavity to measure volatile sulfur compounds for halitosis diagnosis.
2 visits (Day 0 and Day 7)
Trial Site Locations
Total: 1 location
1
Clinique dentaire
Strasbourg, France, 67000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
0
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