Evaluating Kefir Mouthwash Compared to Chlorhexidine for Improving Oral Health in Adults with Moderate Gingivitis

What this Trial Is About

Researchers are evaluating the effectiveness of kefir mouthwash in improving oral health by studying its impact on gingival inflammation, plaque, oral hygiene, and bad breath in adults with moderate gingivitis. This trial compares kefir mouthwash to the standard chlorhexidine 0.12% mouthwash over a 28-day period, with assessments at the start, day 14, and day 28. The study uses a triple-blind, randomized design involving healthy adults aged 18 to 28 years. Participants will be randomly assigned to use either kefir mouthwash or chlorhexidine. Kefir mouthwash is prepared from probiotic cultures mixed with 3% fat milk and used twice daily, 30 minutes after brushing, for one minute each time. The chlorhexidine group uses 0.12% chlorhexidine mouthwash following the same schedule and instructions. Both mouthwashes are provided in identical bottles labeled only by codes to maintain blinding. During the trial, researchers will measure oral health using the Gingival Index, Plaque Index, Simplified Oral Hygiene Index, and halitosis levels with a Hali Meter. Saliva samples will be collected to analyze inflammatory markers IL-1b2 and IL-10 at baseline, day 14, and day 28. Participants adherence will be monitored through daily logs, electronic reminders, and follow-up visits. Non-compliance may lead to exclusion from the study.

Role of Kefir Mouth Wash in Oral Health Status Amelioration