Actively Recruiting
EXercise Magnetic Resonance Imaging in Patients With Obesity Associated Heart Failure With Preserved Ejection Fraction (EXPOSURE) Study
Led by University Medical Center Groningen · Updated on 2024-07-23
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how epicardial fat, the fat directly around the heart, affects heart function in people with heart failure with preserved ejection fraction (HFpEF). The study focuses on understanding how this fat may limit heart movement and impact the interaction between heart chambers during exercise. This is an observational study including 50 patients with HFpEF, measuring differences in heart function based on fat volume around the heart. Participants will undergo cardiac magnetic resonance imaging (CMR) both at rest and during exercise stress testing. They will be divided into groups with high or low epicardial fat volume. The study will assess multiple heart function measures during peak exercise, such as heart chamber strain, blood flow in the pulmonary artery, and cardiac output. These measures will also be compared between men and women. During the study, patients will complete exercise tests on a bicycle while undergoing CMR scans. Researchers will evaluate heart function changes from rest to peak exercise. They will collect data on heart chamber movement, blood flow, and oxygen use. The main outcome is the difference in left ventricular shape at peak exercise. Additional outcomes include heart strain, blood flow measures, and cardiac output. The study aims to understand how epicardial fat influences heart performance in HFpEF.
CONDITIONS
Brief Title
Exercise Magnetic Resonance Imaging in Patients With Obesity Associated Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signs and symptoms of heart failure according to the European Society of Cardiology guideline
- Left ventricular ejection fraction of 40% or higher
- HFA-PEFF score 5 or higher, or score 2-4 with positive stress test
- Age over 18 years
- In normal sinus rhythm
- Able to perform a bicycle exercise test
- Willing to sign informed consent
You will not qualify if you...
- Body weight over 140 kg
- Atrial fibrillation or other significant arrhythmia during assessment
- Contraindications for cardiac magnetic resonance imaging (e.g., claustrophobia, implanted cardiac devices)
- Recent myocardial infarction, coronary intervention, or bypass surgery within the last 3 months, or untreated severe coronary artery stenosis
- More than moderate left-sided valve disease
- Complex congenital heart disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo cardiac magnetic resonance imaging and exercise testing to assess heart function and epicardial fat volume.
1 visit (in-person)
Duration - Up to study completion
Participants are observed for changes in cardiac function and ventricular interdependence related to epicardial fat volume.
No additional visits required
Trial Site Locations
Total: 1 location
1
University Medical Center Groningen
Groningen, Netherlands, 9713GZ
Actively Recruiting
Research Team
T
Thomas M Gorter, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here