Effects of Resistance Training on Brain Health and Thinking Abilities in Perimenopausal Women Ages 40 to 55

What this Trial Is About

Researchers are studying the effects of exercise on brain health and thinking abilities in perimenopausal females aged 40 to 55 who report difficulties with their memory and thinking. The study aims to fill a knowledge gap on whether resistance training can improve cognitive health during perimenopause, a time linked to increased risk of dementia and cognitive decline in females. This is a randomized, assessor-blinded trial comparing two types of exercise programs over 26 weeks. Participants will be randomly assigned to one of two groups progressive resistance training PRT or balance, flexibility, and tone exercises BAT. The PRT group will attend 1-hour sessions twice a week, including warm-up, resistance training using weights or machines, and cool-down. The BAT group will also participate in 1-hour group sessions twice a week focusing on Pilates, yoga poses, Kegel exercises, stretching, and relaxation techniques. The intervention lasts for six months. During the study, participants will undergo assessments at baseline, 13 weeks, and 26 weeks. These include cognitive tests like the Rey Auditory Verbal Learning Test, muscle strength measurements, blood pressure, sleep quality evaluations, psychological questionnaires, and quality of life surveys. Researchers will also monitor heart health, inflammation markers, diet, physical activity, and brain-related biomarkers. The study tracks changes over time to understand how exercise might support brain and overall health in perimenopausal females.

Exercise in Perimenopause to Improve Cognitive Health