Study protocol for a randomized trial examining a peer grief support approach for people grieving drug overdose deaths.
Karen Chan Osilla, Katherine E Watkins, Tanya Lord...
https://pubmed.ncbi.nlm.nih.gov/41668117/Actively Recruiting
Led by RAND · Updated on 2025-08-21
340
Participants Needed
4
Research Sites
213 weeks
Total Duration
This research aims to help people who have lost a loved one to an accidental drug overdose, focusing on the unique and intense grief they experience. These individuals often face feelings like guilt, shame, and blame, which can make their grief harder and stop them from seeking support. The study is part of a larger effort to address the opioid crisis by improving grief support for those affected, especially since this group is at higher risk for prolonged grief disorder, substance use problems, PTSD, depression, and suicidal thoughts. Participants will be divided randomly into two groups. One group will be paired with a peer grief support specialist who follows the RIVER model developed by Peer Community Support Partners. They will also get a booklet with information about grief and a list of local support resources. The other group will receive just the booklet and resource list, which is considered enhanced usual care. The study will compare these two approaches to see how well the RIVER peer support helps. People in the study will be assessed at the start and then again at 3, 6, and 12 months. Researchers will measure grief symptoms, how participants cope and accept their loss, their feelings of connection, avoidance of grief reminders, substance use, depression, posttraumatic stress symptoms, and physical pain. The study seeks to understand how these supports impact participants over time and improve their wellbeing after overdose loss.
CONDITIONS
Families Left Behind
A
Alison Athey, PhD
K
Karen Osilla, PhD
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RAND
Lead Sponsor
Stanford University
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Peer Grief Support + Enhanced Care as Usual (RIVER) | Enhanced Care as Usual (Booklet + Resources) |
|---|---|---|
| What it is | A structured peer-delivered grief support program (RIVER) developed to help adults grieving a loved one lost to drug overdose, delivered alongside a psychoeducation booklet and local grief resources. | Provision of a psychoeducational grief booklet developed by a grief education organization, plus a list of local grief resources and services, without structured peer support. |
| Role in study | This is the active intervention arm receiving peer support plus enhanced care. | This is the comparator arm, representing enhanced care as usual without added peer support. |
| Primary use | To support bereaved adults through structured peer-facilitated sessions, aiming to address grief, coping, and connection after drug-overdose loss. | To provide evidence-informed grief education and access to local support resources for people affected by overdose loss. |
| How it is given or performed | Delivered as a structured peer support process by trained individuals, in addition to receiving a grief booklet and resource list. Details such as session number and format are protocol-determined (not detailed in summary). | Participants are given a psychoeducational booklet and a resource list to use on their own, without guided peer-led sessions. |
| Evidence status | Efficacy for reducing grief and improving coping after overdose loss is being evaluated; published outcome evidence is not yet available. | Being used as a comparator for the active intervention; outcome evidence specific to this population and delivery format is also not yet available from this trial. |
| Important limitations | Results for RIVER are not yet established; no published outcome or long-term follow-up data exist at this time. Peerled support may vary in delivery across facilitators. | This approach provides only written information and access to resources; it does not include interpersonal peer support, and study data on its benefits in this specific context are limited. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - 12 months
Participants receive peer grief support or enhanced care as usual to address prolonged grief and substance use disorders.
1 baseline visit and 3 follow-up visits at 3, 6, and 12 months
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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Karen Chan Osilla, Katherine E Watkins, Tanya Lord...
https://pubmed.ncbi.nlm.nih.gov/41668117/Karen Chan Osilla, Katherine E Watkins, Tanya Lord...
https://pubmed.ncbi.nlm.nih.gov/40894007/RAND
Lead Sponsor
Stanford University
Collaborating Sponsor