One-Week Water-Allowed Fasting Study to Understand Its Effects on Human Metabolism, Immunity, and Brain Function

What this Trial Is About

Researchers are investigating the effects of a 1-week complete fast, allowing water intake, on human immune function, metabolism, and brain function. This study focuses on exploring the biological mechanisms behind these changes using a multi-omics approach, aiming to provide new insights into fastings role in disease prevention and treatment. Current evidence mainly comes from animal studies, so this research seeks to fill gaps in human clinical data. Participants will undergo a full fast for seven days during which they may drink water freely. The study includes multiple follow-up periods baseline before fasting, end of fasting at day 8, one week re-feeding at day 15, four weeks re-feeding at day 36, and twelve weeks re-feeding at day 92. Throughout these times, various biological samples and assessments will be collected and analyzed. During the study, participants will provide blood, urine, and stool samples at specified time points to measure cytokines, metabolites, intestinal flora, blood lipids, insulin, thyroid function, and body fat percentage. Brain function will also be evaluated. These repeated measures allow researchers to track changes from before fasting through different re-feeding stages. The total participation spans about three months, including monitoring and safety evaluations throughout the study period.

Fasting Effects on Metabolism and Immunity Study in Human