Study on the Effect and Mechanism of Fasting on Human Metabolism and Immunity

What this Trial Is About

This research aims to investigate the effects of one-week fasting, allowing water intake, on human immune function, metabolism, and brain function. It explores how fasting influences these areas from a multi-omics perspective and seeks to better understand the biological mechanisms behind these changes. The study addresses gaps in current knowledge by focusing on human subjects rather than animals, providing new insights into fasting's role in disease prevention and treatment. Participants will undergo a one-week fasting period without food but with unlimited water drinking. The study measures changes over several time points: baseline (day 0), end of fasting (day 8), one week of re-feeding (day 15), four weeks of re-feeding (day 36), and twelve weeks of re-feeding (day 92). This schedule allows researchers to observe immediate and longer-term effects of fasting followed by re-feeding. During the study, blood, urine, and stool samples will be collected at each time point to measure changes in cytokine and metabolite levels. These measurements help assess immune and metabolic responses to fasting. Participants will be monitored throughout the fasting and re-feeding periods to understand the impact on brain function and overall health. The total study duration for each participant is 92 days, including baseline, fasting, and follow-up phases.

Fasting Effects on Metabolism and Immunity Study in Human