Actively Recruiting
Mechanisms of Fasting Induced Reduction in Energy Expenditure
Led by ETH Zurich · Updated on 2025-05-30
40
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
Sponsors
E
ETH Zurich
Lead Sponsor
U
University Hospital, Basel, Switzerland
Collaborating Sponsor
AI-Summary
What this Trial Is About
Fasting reduces the energy consumption of the human body. The extent of this adaptation varies significantly between different individuals. The aim of this research project is to investigate how this adaptation of the metabolism is regulated by the body. For this purpose, we will first measure how the so-called basal metabolic rate of the body reacts to a short-term fasting of 24 h in a preliminary study. Those subjects with a particularly pronounced and those subjects with an only slightly pronounced reaction of the basal metabolic rate will be invited to the main study. Here, in random order (24 h fasting vs. 8 h fasting), the following is compared * how the basal metabolic rate of the body reacts to the reduced energy intake. * how the energy metabolism increases after a test meal * what role in particular the thyroid hormones play in this adaptation. In addition, a sample of the subcutaneous adipose tissue is taken in each case and it is examined how the regulation of metabolic processes at the cellular level.
CONDITIONS
Official Title
Mechanisms of Fasting Induced Reduction in Energy Expenditure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 40 years
- Body mass index between 18.0 and 27.0 kg/m²
You will not qualify if you...
- Chronic medical conditions requiring treatment (e.g., kidney failure, liver dysfunction, cardiovascular disease, diabetes mellitus)
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to follow study procedures
- Participation in another investigational drug study within 30 days before or during this study
- Previous participation in this study
- Investigator, family members, employees, or dependents enrolled
- Hypothyroidism or hyperthyroidism
- Pregnancy, breastfeeding, or menopausal status
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Basel
Basel, Switzerland
Actively Recruiting
Research Team
M
Matthias Betz
CONTACT
R
Rahel Loeliger
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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