Actively Recruiting
Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting
Led by University of Minnesota · Updated on 2025-10-15
15
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore how prolonged fasting affects metabolic and cell markers in the blood and how these changes might be used to influence cell-based disease models such as cancer, metabolic syndrome, and diabetes. It focuses on understanding how fasting activates the immune system and alters metabolism, which could lead to new treatments that mimic fasting effects without the need to fast. The study involves healthy adults aged 18 to 65 years without other medical conditions. Participants will fast with water only for up to 60 hours while wearing continuous glucose monitors to track blood sugar levels. The study observes the effects of fasting on blood metabolites and their impact on cell models in the lab. This investigation includes collecting blood samples before and after fasting to analyze changes related to cell viability, signaling, function, and inflammation. Throughout the study, participants will be monitored for safety and feasibility of prolonged fasting. Researchers will measure how well participants can complete the fasting period and evaluate blood markers at baseline and after fasting. The study lasts a few days around the fasting period, with detailed assessments on day 4 to determine fasting feasibility and the biological effects of fasting on serum and cell models.
CONDITIONS
Brief Title
Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages of 18-65 years old
- Not pregnant
- No comorbid conditions
- BMI of 18.5-29.9
- Has a smartphone
You will not qualify if you...
- Concern for active eating disorder per screening questionnaire
- Self-reported eating disorder or history of eating disorder
- History of hypoglycemia or contraindication for Prolonged Fasting
- Weight <120lbs
- History of blood donation within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 60 hours
Participants fast with water for up to 60 hours while wearing continuous glucose monitors to observe metabolic and therapeutic effects.
Continuous glucose monitoring during fasting period
Duration - 1 day
Participants provide blood samples before and after fasting to assess plasma effects on cell-based disease models.
2 visits (baseline and after fasting)
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
L
Lesia Lysne
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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