Actively Recruiting
Feminizing Treatment in Transgender Women and Non-binary Persons BODY IDENTITY CLINIC - ESTROGEN
Led by Odense University Hospital · Updated on 2025-03-21
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of feminizing hormone treatment on cardiovascular health in transgender women and non-binary persons. This observational cohort study will follow 100 participants who are starting gender affirming hormone treatment. The goal is to understand how the treatment influences heart health and cardiovascular risk over time. Participants will receive standard feminizing hormone treatment as part of the study. The follow-up will occur at 1 year, 3 years, 5 years, and 10 years after starting treatment. Researchers will monitor cardiovascular outcomes including coronary plaque formation, heart function using echocardiograms, and various cardiovascular risk markers measured in blood and urine. Throughout the study, participants will undergo coronary CT angiograms to assess plaque development and echocardiograms to evaluate heart function. Blood pressure and other cardiovascular risk markers will also be checked periodically. The main outcome measured is coronary plaque formation after 1 year, with longer-term cardiovascular effects observed during extended follow-ups. The total duration of participation may last up to 10 years.
CONDITIONS
Brief Title
Feminizing Treatment in Transgender Women and Non-binary Persons
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Assigned male at birth and eligible for gender affirming feminizing treatment
- Age 18 years or older
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 years
Participants who undergo routine feminizing hormone treatment are observed for cardiovascular health and plaque formation.
Follow-up visits after 1 year, 3 years, 5 years, and 10 years
Trial Site Locations
Total: 1 location
1
OdenseUH
Odense, Denmark, 5230
Actively Recruiting
Research Team
D
Dorte Glintborg
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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