Effects of Testosterone Treatment on Heart Health, Muscle Strength, Aggression, and Fitness in Transgender Men at the Body Identity Clinic

What this Trial Is About

This research aims to study transgender men and non-binary persons before and during testosterone treatment. It focuses on understanding how testosterone affects cardiovascular health, muscle strength and power, aggression, quality of life, as well as cardiac and respiratory function. The study observes these effects over an extended period to provide insights into the short- and long-term impact of masculinizing treatment. The study is a prospective, single-center observational cohort conducted at the Body Identity Clinic, where participants undergo assessments at the start and after 1, 3, 5, and 10 years of testosterone therapy. There is no intervention administered by the study team, as it observes participants receiving testosterone treatment as part of their gender-affirming care. Participants will be evaluated through various tests and questionnaires at multiple time points over 10 years. These include measurements of heart plaque development, calcium scores, muscle strength and power, oxygen consumption, hormone levels, inflammation markers, cardiovascular risk indicators, and assessments of aggression, quality of life, heart, and respiratory function. All findings will be used to better understand the effects of testosterone treatment in this population.

Transgender Men, Non-binary Persons and Testosterone Treatment BODY IDENTITY CLINIC