Actively Recruiting
Led by Marianne Andersen · Updated on 2025-08-13
200
Participants Needed
1
Research Sites
N/A
Total Duration
This research aims to study transgender men and non-binary persons before and during testosterone treatment. It focuses on understanding how testosterone affects cardiovascular health, muscle strength and power, aggression, quality of life, as well as cardiac and respiratory function. The study observes these effects over an extended period to provide insights into the short- and long-term impact of masculinizing treatment. The study is a prospective, single-center observational cohort conducted at the Body Identity Clinic, where participants undergo assessments at the start and after 1, 3, 5, and 10 years of testosterone therapy. There is no intervention administered by the study team, as it observes participants receiving testosterone treatment as part of their gender-affirming care. Participants will be evaluated through various tests and questionnaires at multiple time points over 10 years. These include measurements of heart plaque development, calcium scores, muscle strength and power, oxygen consumption, hormone levels, inflammation markers, cardiovascular risk indicators, and assessments of aggression, quality of life, heart, and respiratory function. All findings will be used to better understand the effects of testosterone treatment in this population.
CONDITIONS
Transgender Men, Non-binary Persons and Testosterone Treatment BODY IDENTITY CLINIC
You may qualify if you...
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At baseline
Participants undergo initial evaluations including assessments of cardiovascular, muscle strength, respiratory function, hormone levels, and inflammatory markers at the start of testosterone therapy.
1 baseline visit (in-person)
Duration - 10 years
Participants are observed over 10 years with repeated assessments to monitor effects of testosterone treatment on cardiovascular health, muscle strength, respiratory function, hormone levels, and quality of life.
Visits at 1, 3, 5 and 10 years (in-person)
Total: 1 location
1
Odense University Hospital
Odense, Denmark, 5000
Actively Recruiting
M
marianne andersen, Professor
L
Louise Christensen, MD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Have more questions? Get in touch with our team for quick support
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Louise Lehmann Christensen, Dorte Glintborg, Tine Taulbjerg Kristensen...
https://pubmed.ncbi.nlm.nih.gov/33376186