Study of Puberty Suppression Effects on Insulin Sensitivity and Vascular Health in Transgender Female and Cisgender Male Youth Aged 9 to 14 Years

What this Trial Is About

Researchers are studying how puberty suppression affects insulin sensitivity, metabolic rate, and vascular health in transgender female youth compared to cisgender male controls. This observational study focuses on youth aged 9 to 14 years who are in early stages of puberty Tanner Stage 2-3. The goal is to understand changes in these health measures before and six months after starting treatment with a gonadotropin releasing hormone agonist. The study includes two groups transgender females planning to begin puberty suppression treatment within two months, and matched cisgender male controls. Researchers will observe and compare changes in insulin sensitivity, body composition, resting metabolic rate, endothelial function, arterial stiffness, and cerebrovascular function at the start and six months after treatment initiation. Participants will undergo health assessments at baseline and six months later, including measures of insulin sensitivity, body fat and muscle mass, metabolic rate, and vascular health. The study monitors changes over time to understand the effects of puberty suppression. The total duration of participation is approximately six months, during which researchers will collect data to evaluate the treatments impact on cardiometabolic health.

Puberty Suppression and Cardiometabolic Health