Actively Recruiting
Fully Automated High-Throughput Quantitative MRI of the Liver
Led by University of Wisconsin, Madison · Updated on 2026-03-12
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
N
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a new fully automated magnetic resonance imaging (MRI) method designed to improve liver imaging. This study includes participants who have known or suspected liver disease, iron overload syndrome, or are healthy adults. The goal is to develop an efficient MRI exam that provides accurate, low-cost quantitative evaluation of chronic liver disease in less than 5 minutes of MRI suite time. The study aims to compare a new free-breathing 2D chemical shift encoded MRI (CSE-MRI) method with a reference 3D CSE-MRI method to confirm accuracy and reliability. The research involves a single-button push, fully automated MRI protocol that uses artificial intelligence for automated image prescription and innovative MRI "Smart Suite" technology. Participants are divided into six substudies, including healthy volunteers and patients with liver fat or iron overload. Depending on the substudy, participants undergo MRI scans lasting from under 10 minutes to about 3.5 hours, with some scanned multiple times at different MRI field strengths (1.5T and 3T). Some participants will wear RFID or Bluetooth bracelets to track MRI suite time and workflow. Participants will attend one study visit where they undergo MRI scans, anthropometric measurements, and other assessments. The study measures include accuracy and repeatability of liver fat and iron quantification, image quality, technical success of the automated exam, and total time spent in the MRI suite. Data is collected via imaging and automated analysis, with participants monitored for about one day during the visit. This research is sponsored by the University of Wisconsin, Madison.
CONDITIONS
Brief Title
Fully Automated High-Throughput Quantitative MRI of the Liver
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older for substudies 1, 2, 4, and 5
- Age 7 years or older for substudies 3 and 6
- Known or suspected liver iron overload or elevated liver fat for substudy 3
- Scheduled for a clinical abdominal MRI exam for substudy 6
You will not qualify if you...
- Contraindication to MRI such as pacemaker, metallic implants, or claustrophobia
- Pregnant or trying to become pregnant
- Need for intravenous conscious sedation for MRI (allowed mild oral anxiolytics with conditions in substudy 3)
- Sedation required for MRI in substudy 6
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day (1 study visit, up to 3.5 hours)
Participants undergo MRI scans using a fully automated, single-button push MRI protocol to evaluate liver fat and iron using a free-breathing 2D chemical shift encoded MRI method.
1 research visit lasting up to 3.5 hours; includes multiple scans depending on substudy assignment
Duration - Duration of clinical imaging visits as applicable
Participants are equipped with RFID or Bluetooth bracelets to track MRI suite time and workflow during the research and clinical imaging visits.
Tracking occurs during research and clinical MRI visits; visit counts vary by substudy
Trial Site Locations
Total: 1 location
1
University of Wisconsin
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
R
Radiology Studies
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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