Actively Recruiting
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
Led by Gødstrup Hospital · Updated on 2026-01-27
150
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
Sponsors
G
Gødstrup Hospital
Lead Sponsor
U
University of Aarhus
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research focuses on people with Turner syndrome (TS) to explore genetic and epigenetic factors linked to sensorineural hearing loss (SNHL). The study aims to identify specific DNA methylation patterns and RNA expression profiles related to SNHL in TS, and to understand if epigenetics plays a key role in unexplained cases of SNHL. Turner syndrome serves as a model to investigate inner ear dysfunction and its connection to epigenetic profiles. Participants are grouped into three categories: individuals with TS and SNHL, individuals with TS without SNHL, and healthy age-matched controls without TS or SNHL. The study involves observational assessments without drug or device interventions. Participants will undergo ear exams, hearing and balance tests, blood draws, MRI scans, and cone-beam computed tomography (CBCT) scans. During the study, researchers will evaluate epigenetic profiles, hearing abilities, vestibular (balance) status, and structural ear malformations. These assessments will occur from 2024 through 2026. The study will monitor participants' inner ear structure and function, correlating findings with genetic and epigenetic data. The total participation period extends through 2027, allowing for comprehensive data collection and analysis.
CONDITIONS
Brief Title
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years old
You will not qualify if you...
- Contraindications for MRI or CBCT scans
- Serious medical disorders
- Neurological or psychiatric disorders of any kind
- Use of medication known to influence inner ear function
- Medical history with dizziness or hearing problems (controls only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 2024 to 2026
Participants undergo assessments of hearing ability, vestibular status, and imaging for structural malformations.
1 to 3 visits depending on group assignment
Duration - 2024 to 2026
Participants are observed over time to study epigenetic profiles related to inner ear dysfunction.
Trial Site Locations
Total: 1 location
1
ENT department of Gødstrup Hospital
Herning, Denmark, 7400
Actively Recruiting
Research Team
L
Louise Hill-Madsen, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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