Actively Recruiting
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
Led by Gødstrup Hospital · Updated on 2026-01-27
150
Participants Needed
1
Research Sites
129 weeks
Total Duration
On this page
Sponsors
G
Gødstrup Hospital
Lead Sponsor
U
University of Aarhus
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS). The aim is to find out if there are specific DNA methylation patterns and/or RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile. The main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases? Turner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL). Participants will undergo the following tests: * Ear examinations * Hearing tests * Balance tests * Blood tests * MRI scans * CBCT (cone-beam computed tomography) scans
CONDITIONS
Official Title
Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years old
You will not qualify if you...
- Contraindications for MRI or CBCT scans
- Serious medical disorders
- Neurological or psychiatric disorders of any kind
- Use of medication known to influence inner ear function
- History of dizziness or hearing problems (controls only)
AI-Screening
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Trial Site Locations
Total: 1 location
1
ENT department of Gødstrup Hospital
Herning, Denmark, 7400
Actively Recruiting
Research Team
L
Louise Hill-Madsen, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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