Genetic Research on Early-Onset Dementia and Memory Loss in Adults 35 and Older

What this Trial Is About

Researchers are investigating genetic factors that may influence the risk and progression of early-onset dementia, including Alzheimers disease, mild cognitive impairment, and other types of dementia. This study includes people from all ethnic backgrounds, focusing on those who experience memory loss before age 70 as well as cognitively healthy individuals with a family history of dementia. The goal is to better understand the genetics behind these conditions across a diverse population. Participants are grouped based on their condition those with mild cognitive impairment starting before age 70, those diagnosed with Alzheimers or other dementias before age 70, cognitively healthy individuals over age 35 with a family history of dementia, and those diagnosed with early-onset dementia prior to age 65. The study involves collecting blood samples to identify genetic variants, brief memory tests, and medical questionnaires to gather health history information. During the study, participants will undergo genetic testing from blood samples and assessments of their cognitive function through brief memory exams. Medical history information is also collected to provide context for the genetic findings. Researchers will monitor genetic risk variants and changes in blood biomarkers related to early-onset dementia over a two-year period. This observational study allows participants to contribute data without receiving experimental treatments, and the total duration may vary depending on individual involvement.

Genetic Studies of Early-onset Dementia