Actively Recruiting
Genetic Studies of Early-onset Dementia
Led by Columbia University · Updated on 2026-04-29
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
U
University of Miami
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating genetic factors that may influence the risk and progression of early-onset dementia, including Alzheimer's disease, mild cognitive impairment, and other types of dementia. This study includes people from all ethnic backgrounds, focusing on those who experience memory loss before age 70 as well as cognitively healthy individuals with a family history of dementia. The goal is to better understand the genetics behind these conditions across a diverse population. Participants are grouped based on their condition: those with mild cognitive impairment starting before age 70, those diagnosed with Alzheimer's or other dementias before age 70, cognitively healthy individuals over age 35 with a family history of dementia, and those diagnosed with early-onset dementia prior to age 65. The study involves collecting blood samples to identify genetic variants, brief memory tests, and medical questionnaires to gather health history information. During the study, participants will undergo genetic testing from blood samples and assessments of their cognitive function through brief memory exams. Medical history information is also collected to provide context for the genetic findings. Researchers will monitor genetic risk variants and changes in blood biomarkers related to early-onset dementia over a two-year period. This observational study allows participants to contribute data without receiving experimental treatments, and the total duration may vary depending on individual involvement.
CONDITIONS
Brief Title
Genetic Studies of Early-onset Dementia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 35 years or older
- Individuals with memory concerns or diagnosed with dementia
- Family members of affected individuals who are cognitively healthy and unrelated controls
You will not qualify if you...
- Diagnosis of Huntington's disease
- History of traumatic brain injury
- Drug or alcohol abuse
- Diagnosis of schizophrenia
- Exceptions apply if family members of a dementia-affected individual
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Initial assessment
Participants undergo blood draws, neurocognitive testing, and medical questionnaires to collect genetic and clinical information.
1 visit (in-person)
Duration - Up to 2 years
Participants are observed over time to track genetic risk variants and changes in blood biomarkers associated with early-onset dementia.
Periodic visits during the 2-year observation period
Trial Site Locations
Total: 1 location
1
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
P
Pamela Del Rosario
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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