Actively Recruiting
Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants
Led by Medical College of Wisconsin · Updated on 2026-01-26
1100
Participants Needed
1
Research Sites
1148 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if sequence variations in genes involved in the development and function of vulnerable organs increases susceptibility to chronic lung disease (CLD) and other diseases affecting premature infants, such as necrotizing enterocolitis (NEC), sepsis, patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH). The study will also determine whether measurement of certain biomarkers in serum will identify infants who will develop these complications of prematurity. Previous studies from this institution and others have identified genetic variants in some genes, such as toll like receptor genes are associated with higher risk of CLD or NEC. The interaction of these variants with other gene variants that can influence the risk of these diseases remains unclear.
CONDITIONS
Official Title
Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants born weighing less than 1500 grams
You will not qualify if you...
- Infants born with congenital heart disease (other than patent ductus arteriosus)
- Major congenital anomalies of the gastrointestinal tract, respiratory tract, or kidneys
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
G
G. Ganesh Konduri, MD
CONTACT
K
Kathleen M Meskin, BSN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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