Actively Recruiting
Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases
Led by University of Manchester · Updated on 2024-09-19
325
Participants Needed
1
Research Sites
413 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The researchers would like to know more about cardiovascular abnormalities in patients with immune-mediated inflammatory diseases (IMID) and with the aim to provide new biomarkers (clinical, blood, imaging) for early diagnosis, prognosis and prediction of CVD in patients with IMID. This is important as there are still many things that are not known about this and finding out more could improve how patients are treated in future. Participants with IMID diagnoses will be recruited from rheumatology/cardiology departments as in-patients or outpatients. Once consented, researchers will collect past, present and future clinical information about them, including routine cardiovascular imaging and blood tests. Participants will also be asked to complete questionnaires at predetermined intervals. The participants could also be approached to take part in the following sub-studies; Biological sub-study, in which blood and urine would be collected; And the Imaging-sub study, in which one or more of Echocardiography, Cardiovascular Magnetic Resonance Imaging (CMR) and Laser Doppler Imaging (LDI) will be performed. Participants with CVD without IMID and healthy volunteers will also be recruited as comparison groups. The research is to be funded by the NIHR Manchester BRC ('Integrated Cardiovascular' and 'Rheumatic \& Musculoskeletal Diseases' themes). Other funding eg Manchester Academic Health Sciences and a recently awarded Medical Research Council Partnership grant will also support this programme. The study will recruit in specialist NHS centres; Recruitment will start in Manchester University Hospitals NHS Foundation Trust.
CONDITIONS
Official Title
Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females
- Age over 18 years
- Able to provide informed consent and sign a consent form
- Diagnosed with an immune-mediated inflammatory disease (IMID) with one of the following: at risk of cardiovascular disease (CVD) but no major adverse cardiovascular events (MACE), new (incident) IMID-CVD with MACE, or established IMID-CVD with previous MACE
- For controls: age 18 or older, able to consent, no known IMID for CVD-no IMID and healthy controls, no known CVD for IMID-no risk CVD and healthy controls
You will not qualify if you...
- Under 18 years of age
- Unable to provide informed consent
- For cardiac MRI imaging: presence of pacemakers, surgical clips in the head, certain inner ear implants, neuro-electrical stimulators, metal fragments in eye or head, pregnancy or breastfeeding
- For MRI with gadolinium contrast: glomerular filtration rate (GFR) less than 30 ml/min/1.73 m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Manchester University NHS Foundation Trust
Manchester, Greater Manchester, United Kingdom, M13 9WL
Actively Recruiting
Research Team
J
James Lawrence, MSc
CONTACT
M
Maya H Buch, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
8
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