Actively Recruiting
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION)
Led by Seoul National University Hospital · Updated on 2025-12-31
11086
Participants Needed
61
Research Sites
458 weeks
Total Duration
On this page
Sponsors
S
Seoul National University Hospital
Lead Sponsor
S
Samjin Pharmaceutical Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will evaluate the efficacy and safety of clopidogrel for primary prevention in patients diagnosed with coronary atherosclerosis on imaging that did not require revascularization therapy. The trial will test the hypothesis that clopidogrel is beneficial in preventing major adverse cardiovascular and cerebrovascular events (MACCE) in patients with subclinical coronary atherosclerosis identified on imaging.
CONDITIONS
Official Title
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged ≥40 years
- Patients with subclinical coronary atherosclerosis identified from coronary CT angiography or coronary angiography within 2 years without clinical events after an imaging study
- Without significant coronary artery stenosis (Diameter stenosis >50%), which needs revascularization
- Agreement to give written informed consent
You will not qualify if you...
- A history of a diagnosed cardiovascular or cerebrovascular disease (Type1 myocardial infarction, heart failure, peripheral artery disease, stroke, transient ischemic attack, carotid artery stenosis>50%, carotid artery intervention)
- A history of coronary artery intervention or coronary artery bypass graft surgery, which needs chronic maintenance of antiplatelet therapy
- Absolute contraindication or allergy to clopidogrel
- Patients receiving anticoagulants for other comorbidities
- A history of Bleeding diathesis, known coagulopathy, or major bleeding, BARC class ≥3, resulting in the stop of antiplatelet agents
- Planned surgery or intervention which needs to stop antiplatelet agents ≥1 month
- Presence of non-cardiac comorbidity with life expectancy ≤ 5 years at randomization
- Females with pregnancy or breast-feeding
- Patients who are thought to be inappropriate for the trial based on physicians' decision
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 61 locations
1
Seoul National University Hospital
Seoul, Other, South Korea, 03080
Actively Recruiting
2
Andong Hospital
Andong, South Korea
Actively Recruiting
3
Dong-A University Hospital
Busan, South Korea
Actively Recruiting
4
Inje University Busan Paik Hospital
Busan, South Korea
Actively Recruiting
5
Kosin University Gospel Hospital
Busan, South Korea
Actively Recruiting
6
Pusan National University Hospital
Busan, South Korea
Actively Recruiting
7
Gyeongsang National University Changwon Hospital
Changwon, South Korea
Actively Recruiting
8
Soonchunhyang University Cheonan Hospital
Cheonan, South Korea
Actively Recruiting
9
Soonchunhyang University Cheonan Hospital
Cheonan, South Korea
Actively Recruiting
10
Soonchunhyang University Cheonan Hospital
Cheonan, South Korea
Actively Recruiting
11
Chungbuk National University Hospital
Cheongju-si, South Korea
Actively Recruiting
12
Hallym University Chuncheon Sacred Heart Hospital
Chuncheon, South Korea
Actively Recruiting
13
Kangwon National University Hospital
Chuncheon, South Korea
Actively Recruiting
14
Kangwon National University Hospital
Chuncheon, South Korea
Actively Recruiting
15
Keimyung University Dongsan Hospital
Daegu, South Korea
Actively Recruiting
16
Yeungnam University Medical Center
Daegu, South Korea
Actively Recruiting
17
Chungnam National University Hospital
Daejeon, South Korea
Actively Recruiting
18
Eulji University Hospital, Daejeon
Daejeon, South Korea
Actively Recruiting
19
Gangneung Asan Hospital
Gangneung, South Korea
Actively Recruiting
20
Chonnam National University Hospital
Gwangju, South Korea
Actively Recruiting
21
Chonnam National University Hospital
Gwangju, South Korea
Actively Recruiting
22
Kwangju Christian Hospital
Gwangju, South Korea
Actively Recruiting
23
Chung-Ang University Gwangmyeong Hospital
Gyeonggi-do, South Korea
Actively Recruiting
24
Eulji University Hospital, Uijeongbu
Gyeonggi-do, South Korea
Actively Recruiting
25
Hallym University Dongtan Sacred Heart Hospital
Gyeonggi-do, South Korea
Actively Recruiting
26
Hallym University Sacred Heart Hospital
Gyeonggi-do, South Korea
Actively Recruiting
27
Inje University Ilsan Paik Hospital
Gyeonggi-do, South Korea
Actively Recruiting
28
Myongji Hospital
Gyeonggi-do, South Korea
Actively Recruiting
29
National Health Insurance Service Ilsan Hospital
Gyeonggi-do, South Korea
Actively Recruiting
30
Sejong General Hospital, Bucheon
Gyeonggi-do, South Korea
Actively Recruiting
31
Soonchunhyang University Bucheon Hospital
Gyeonggi-do, South Korea
Actively Recruiting
32
Yonsei University Yongin Severance Hospital
Gyeonggi-do, South Korea
Actively Recruiting
33
Chonnam National University Hwasun Hospital
Hwasun, South Korea
Actively Recruiting
34
Catholic Kwandong University International St. Mary's Hospital
Incheon, South Korea
Actively Recruiting
35
Gachon University Gil Medical Center
Incheon, South Korea
Actively Recruiting
36
Jeju National University Hospital
Jeju City, South Korea
Actively Recruiting
37
Jesus Hospital, Jeonju
Jeonju, South Korea
Actively Recruiting
38
Gyeongsang National University Hospital
Jinju, South Korea
Actively Recruiting
39
Pohang Stroke And Spine Hospital
Pohang, South Korea
Actively Recruiting
40
Chungnam National University Sejong Hospital
Sejong, South Korea
Actively Recruiting
41
Chung-Ang University Hospital
Seoul, South Korea
Actively Recruiting
42
Chung-Ang University Hospital
Seoul, South Korea
Actively Recruiting
43
Ewha Womans University Seoul Hospital
Seoul, South Korea
Actively Recruiting
44
Ewha Womans University Seoul Hospital
Seoul, South Korea
Actively Recruiting
45
Hallym University Kangdong Sacred Heart Hospital
Seoul, South Korea
Actively Recruiting
46
Hallym University Kangdong Sacred Heart Hospital
Seoul, South Korea
Actively Recruiting
47
Hallym University Kangnam Sacred Heart Hospital
Seoul, South Korea
Actively Recruiting
48
Hanyang University Hospital
Seoul, South Korea
Actively Recruiting
49
Inje University Sanggye Paik Hospital
Seoul, South Korea
Actively Recruiting
50
Kangbuk Samsung Hospital
Seoul, South Korea
Actively Recruiting
51
Korea University Anam Hospital
Seoul, South Korea
Actively Recruiting
52
Korea University Guro Hospital
Seoul, South Korea
Actively Recruiting
53
Kyung Hee University Hospital
Seoul, South Korea
Actively Recruiting
54
Samsung Medical Center
Seoul, South Korea
Actively Recruiting
55
Seoul Medical Center
Seoul, South Korea
Actively Recruiting
56
Seoul Metropolitan Government - Seoul National University Boramae Medical Center
Seoul, South Korea
Actively Recruiting
57
Soonchunhyang University Seoul Hospital
Seoul, South Korea
Actively Recruiting
58
Veterans Health Service Medical Center
Seoul, South Korea
Actively Recruiting
59
Yonsei University Gangnam Severance Hospital
Seoul, South Korea
Actively Recruiting
60
Ulsan University Hospital
Ulsan, South Korea
Actively Recruiting
61
Yonsei University Wonju Severance Christian Hospital
Wŏnju, South Korea
Actively Recruiting
Research Team
J
Jung-Kyu Han, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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