Early Blood Transfusion to Prevent Delirium in Patients 75 and Older With Hip Fractures A Single-Blind Randomized Trial by University of Aarhus

What this Trial Is About

This research aims to find out if early detection of bleeding and quick blood transfusions can help prevent delirium in patients aged 75 and older who have hip fractures. The main question is whether treating anemia sooner reduces the risk of delirium. Researchers will compare early treatment with standard care to see if it lowers delirium risk in these patients. Participants will be divided into two groups. One group will receive blood transfusions promptly within 4 hours if their hemoglobin levels drop below a certain point, with vital signs and delirium screenings done three times daily. The other group will get standard care with delayed hemoglobin testing to avoid early transfusion decisions, but they will also have vital signs and delirium screenings three times daily. During the study, participants will undergo blood tests and have their vital signs monitored three times a day for the first 48 hours after surgery. Follow-up visits will occur at 30 days to assess cognitive function and quality of life, and at 90 days to check hospital readmissions and survival. The main outcome measured is how many participants develop delirium within 48 hours after surgery.

How Bleeding Affects Delirium in Older Patients With Hip Fractures: The IMPROVE-HIP Study