Oxygen Delivery and Lung Expansion Measurement Using Nasal CPAP in Preterm Infants Born Before 35 Weeks

What this Trial Is About

This research aims to better understand how nasal continuous positive airway pressure nCPAP, a common breathing support method, delivers oxygen to preterm infants born before 35 weeks gestation. The study focuses on babies with respiratory distress syndrome or respiratory distress of the newborn who are on nCPAP, investigating how much oxygen actually reaches the babys airway compared to the amount set on the device. This is important to ensure infants receive the right oxygen amount for their health. The study involves placing a small catheter in the infants oropharynx to measure the oxygen delivered directly and wrapping soft electrical impedance tomography EIT bands around the infants chest to monitor lung expansion. These measurements are taken while the infant is receiving nCPAP with an oxygen concentration between 22% and 40% and stable on any pressure level. The study collects data over a 30-minute period to capture oxygen delivery and continuous lung volume changes. Participants will have these special measurements taken during the study session without altering their ongoing treatment. Researchers will sample oxygen at three separate points within the 30-minute timeframe and continuously monitor lung volume throughout. The study tracks how effectively oxygen is delivered and how the lungs expand while on nCPAP. Study participation lasts only as long as the measurement session, with no long-term interventions or treatments required.

How Different Levels of CPAP Affect Oxygen Delivery and Lung Expansion in Preterm Infants