Actively Recruiting
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery of Children With Cerebral Palsy and Typically Developed Children (Control).
Led by Eva Ponten · Updated on 2022-08-18
150
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how muscles are affected in children and adolescents with cerebral palsy (CP) or acquired brain injury (ABI), focusing on the muscle changes that cause weakness, stiffness, joint contractures, and difficulty walking. The study compares muscle and tendon samples from these participants to those from typically developed children undergoing surgery for other reasons. The goal is to understand the underlying mechanisms leading to muscle problems and contractures to guide future treatments that may protect muscle and joint health. During clinically needed orthopedic surgeries, muscle and tendon biopsies along with blood samples are collected from children with CP or ABI and from typically developed controls. These samples are analyzed for inflammatory markers, muscle growth signals, connective tissue growth, and muscle and tendon pathology. By comparing muscles used in walking to those used more voluntarily, and flexor muscles to extensors, researchers aim to uncover differences related to contractures and muscle function. Blood analysis includes measuring pro-inflammatory cytokines and a protective compound called humanin. Participants are involved during their planned surgeries when the necessary samples are taken without affecting clinical function. Clinical data on joint contractures and CP severity are recorded before surgery. The study measures muscle and tendon structure, muscle metabolism, and muscle fiber area over the years 2002 to 2027. This observational research helps deepen understanding of muscle changes in CP and ABI, with participant involvement mainly during surgery and clinical assessments before surgery.
CONDITIONS
Brief Title
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children and adolescents undergoing clinically needed orthopaedic surgery
- Diagnosis of cerebral palsy or acquired brain injury
- Typically developed children and adolescents (control group)
You will not qualify if you...
- For cerebral palsy or acquired brain injury: progressive neurological disease or other metabolic or muscle diseases
- For typically developed controls: cerebral palsy, acquired brain injury, or other metabolic or muscle diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants undergo clinically needed orthopaedic surgery during which muscle biopsies, tendon biopsies, and blood samples are taken for research purposes. Samples are collected without affecting clinical function or biomechanical integrity.
1 surgery visit (in-person)
Duration - Variable depending on clinical care
Participants are observed after surgery as part of routine clinical care. No additional interventions are applied by the study.
Visits as part of routine clinical care
Trial Site Locations
Total: 1 location
1
Karolinska University Hospital
Stockholm, Sweden, 17176
Actively Recruiting
Research Team
E
Eva M Pontén, MD PhD
F
Ferdinand von Walden, MD PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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