Actively Recruiting
Imaging the Pathogenesis of Cerebral Small Vessel Disease
Led by Johns Hopkins University · Updated on 2026-03-03
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to better understand cerebral small vessel disease (CSVD), a condition that can lead to vascular cognitive impairment and dementia (VCID). CSVD is marked by white matter changes seen on MRI scans, which are closely linked to cognitive decline. The study focuses on people at risk for progression of these white matter changes, particularly those with a history of stroke and vascular risk factors such as hypertension, hyperlipidemia, or diabetes. Participants will undergo serial MRI scans using advanced imaging methods to study different aspects of brain changes. The study will track blood-brain barrier disruption, micro-structural damage, and larger brain changes using a variety of MRI techniques including DCE, DSC, ASL, multi-shell DTI, FLAIR, SWI, and T1 imaging. A total of 50 patients will have three MRI scans over approximately 1.25 years to observe progression of the disease. During the study, participants will be closely monitored through these MRI assessments to evaluate the progression of cerebral small vessel disease over one year. The main outcome measured is the progression of the disease as observed through imaging. This observational study does not involve treatment but focuses on detailed imaging to gain insights into disease development and progression, helping to inform future approaches to VCID.
CONDITIONS
Brief Title
Imaging the Pathogenesis of Cerebral Small Vessel Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical or radiographic evidence of ischemic stroke
- At least one vascular risk factor such as hypertension, hyperlipidemia, or diabetes
- Evidence of cerebral small vessel disease on MRI
- Able to complete 3 MRI scans over 1.25 years
You will not qualify if you...
- Unable to complete 3 research MRI scans over 1.25 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1.25 years
Participants undergo MRI scans to assess cerebral small vessel disease and related biomarkers.
3 MRI visits over 1.25 years
Trial Site Locations
Total: 1 location
1
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21205
Actively Recruiting
Research Team
S
Sera Chase
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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