Effect of Daily Plant-Based Oat Drink Rich in Short-Chain Fatty Acids for 12 Weeks on Cardiometabolic Health in Adults at Risk for Metabolic Syndrome

What this Trial Is About

Researchers are investigating the effect of daily consumption of a drink enriched with short-chain fatty acids SCFA on cardiometabolic health in adults at risk for metabolic syndrome. This study focuses on individuals who are overweight with disrupted cholesterol levels, high blood pressure, or elevated blood glucose. The trial aims to understand how SCFA intake influences blood lipids, glucose levels, body measurements, blood pressure, and energy use. Participants will be randomly assigned to consume either an oat-based drink enriched with 15 gL of short-chain fatty acids or a control oat drink daily for 12 weeks. The study includes four visits baseline visit 1, weeks 4 and 8 short visits for measurements, and week 12 final visit. During these visits, metabolic and anthropometric parameters, including body weight, waist and hip circumference, body composition, blood pressure, glucose, insulin, and blood lipids, will be assessed. Throughout the study, participants will undergo detailed evaluations such as fasting and post-meal blood tests, body composition analysis, energy expenditure measurements, appetite assessments, and physical activity monitoring. Researchers will measure fasting triglycerides at the start and end, along with many other secondary outcomes like insulin resistance, blood pressure changes, and gut hormones. The total participation lasts 12 weeks, with multiple assessments to track changes over time.

The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome