Studying How Endoscopic Endonasal Skull Base Surgery Affects Smell and Trigeminal Nerve Function in Adults

What this Trial Is About

Researchers are investigating how often and why problems with smell occur after patients undergo endoscopic endonasal skull base surgery. This surgery is used to treat conditions affecting the area around the pituitary gland and other nearby regions. The study aims to understand how this surgery affects the sense of smell and the trigeminal nerve system, which has not been studied before. The study involves detailed assessments of participants smell and trigeminal function before and after the surgery. Researchers will also collect tissue removed during surgery from the posterior septal mucosa to analyze it at a molecular level. This analysis aims to uncover the biological reasons behind smell and trigeminal dysfunction after the procedure. Participants will be evaluated from the time they enroll until six months after surgery, with follow-up extending up to three years to study the causes of dysfunction. The study measures include the frequency of smell and trigeminal problems and the risk factors contributing to these issues. Participants will undergo clinical assessments and tissue analysis to help researchers understand these effects thoroughly.

The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction