Actively Recruiting
The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: a Cross-sectional Study
Led by The Hong Kong Polytechnic University · Updated on 2024-11-26
80
Participants Needed
3
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how chronic non-specific low back pain (CNSLBP), a common condition in older adults, may affect cognitive functions, especially executive functions like memory, attention, and problem-solving. The study aims to understand whether brain changes caused by CNSLBP relate to cognitive decline, using brain imaging to explore structural and functional differences between older adults with CNSLBP and healthy peers. This observational study compares two groups: older adults aged 60 to 85 with CNSLBP lasting at least 3 months and an average pain intensity of 5 or higher, and healthy controls without recent low back pain. Participants will not receive any treatment as part of the study. The study uses brain scans and cognitive tests to examine brain structure, function, and executive abilities. Participants will undergo assessments including pain intensity, mood tests, disability evaluation, and various cognitive tests performed both inside and outside of MRI scans. Additional measures like physical activity, sleep quality, and frailty status will also be collected. The study monitors brain changes and cognitive function to better understand how CNSLBP impacts older adults, with all measures taken at the baseline visit.
CONDITIONS
Brief Title
The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Older adults with and without chronic non-specific low back pain aged between 60 and 85 years
- Normal cognitive function (Hong Kong Montreal Cognitive Assessment score of 26 or higher)
- Right-handed
- Cantonese speaking
- At least 6 years of formal education and able to read and write Chinese
- Agree to sign an informed consent form
- Able to communicate via email or text message for electronic data collection
You will not qualify if you...
- Unable to walk without assistance from another person (canes or walkers allowed)
- Specific causes of low back pain such as spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral fracture, or spinal infection
- Other musculoskeletal conditions like fibromyalgia or pain in the neck or knee
- History of lumbar or lower extremity surgery
- History of neurological or psychiatric disorders, including stroke, brain surgery, head trauma, schizophrenia, or multiple personality disorder
- History of cancer
- Specific inflammatory disorders such as rheumatoid arthritis, rheumatica, scleroderma, lupus, or polymyositis
- Unexplained weight loss of 20 pounds or more in the past year
- Cauda equina syndrome
- Uncorrected vision problems
- Drug or alcohol addiction
- Use of alcohol, opioids, or benzodiazepines within 24 hours before the experiment
- Claustrophobia
- Contraindications for MRI based on safety screening at The Hong Kong Polytechnic University facility
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants complete baseline assessments including pain intensity, cognitive function tests inside and outside MRI scanning, psychological evaluations, and physical activity assessments.
1 visit (in-person)
Trial Site Locations
Total: 3 locations
1
University Research Facility in Behavioral and Systems Neuroscience
Hong Kong, Hong Kong, Hong Kong, 999077
Actively Recruiting
2
Arnold YL Wong
Hong Kong, None Selected, Hong Kong
Actively Recruiting
3
Department of Rehabilitation Sciences
Hong Kong, Hong Kong, 999077
Actively Recruiting
Research Team
F
Frank F Huang, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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