Study on How Chronic Non-Specific Low Back Pain Affects Brain Function and Cognition in Older Adults Aged 60 to 85

What this Trial Is About

Researchers are investigating the impact of chronic non-specific low back pain CNSLBP on cognitive functions, particularly executive functions, in older adults aged 60 to 85 years. The study aims to understand the brain mechanisms connecting CNSLBP with cognitive decline by comparing pain intensity, executive functions, brain structure, and brain function between older adults with CNSLBP and healthy age-matched controls. This longitudinal study seeks to provide insights into how CNSLBP may affect brain changes and executive function over time. Participants include older adults with CNSLBP lasting at least 3 months and experiencing moderate pain, as well as healthy controls without CNSLBP in the past 36 months. No interventions are assigned as this is an observational study. The study uses brain imaging and cognitive tests at baseline and after 6 months to observe changes and relationships between pain, brain structure, and cognition. During the study, participants undergo assessments of pain intensity, brain imaging, and various cognitive and physical tests at the start and six months later. These include tests for depression, anxiety, stress, disability, cognitive flexibility, working memory, inhibition, sleep quality, frailty, balance, and mobility. Data collection partly uses electronic communication. The total participation duration covers baseline and 6-month follow-up visits to track changes over time.

The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: A Longitudinal Study