Actively Recruiting
Influence of the Gut Microbiome on Blueberry Polyphenol Metabolites
Led by Colorado State University · Updated on 2026-05-26
125
Participants Needed
1
Research Sites
43 weeks
Total Duration
On this page
Sponsors
C
Colorado State University
Lead Sponsor
F
Florida State University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how differences in the gut microbiome affect how people's bodies process blueberry polyphenols. This study aims to categorize individuals into groups called "metabotypes" based on their metabolite profiles after consuming blueberries. The goal is to see if the gut microbiome can predict these metabotypes using advanced multi-omic techniques. Participants will consume a single dose of a standardized blueberry beverage made from 22 grams of freeze-dried blueberry powder mixed in water after fasting overnight. The study includes a screening visit, a test day with blood sampling over 8 hours, and a 24-hour follow-up visit. During the test day, blood samples will be collected at multiple times to track blueberry polyphenol metabolites, and standardized low-polyphenol meals will be provided. Participants will also collect stool and urine samples before and after the test day. Throughout the study, participants will complete questionnaires on diet, physical activity, sleep quality, gastrointestinal symptoms, and social health factors. Biological samples including blood, urine, and stool will be analyzed to study polyphenol metabolism and gut microbiome features. The main measurements include the area under the curve, maximum concentration, and time to maximum concentration of blueberry polyphenol metabolites in the blood. The study is expected to last from screening through a 24-hour follow-up, with compensation for participants' time.
CONDITIONS
Brief Title
Influence of the Gut Microbiome on Blueberry Polyphenol Metabolites
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults 18 years of age or older
- Able and willing to provide informed consent
- Willing and able to follow all study procedures and visit requirements
You will not qualify if you...
- Under 18 years of age
- Pregnant or breastfeeding
- Chronic diseases such as cardiovascular disease, diabetes, cancer, kidney, liver, gastrointestinal, or pancreatic disease
- Use of medications for chronic diseases that may affect study outcomes
- Conditions affecting nutrient absorption (e.g., inflammatory bowel disease, celiac disease, gastroparesis)
- Anemia (hemoglobin below 13.5 g/dL in men or below 12.0 g/dL in women)
- Body mass index (BMI) 18.5 kg/m2 or lower
- Antibiotic use within the past 2 months
- Recent blood draw within 1 week before participation
- Participation in another diet or exercise research study
- Known allergy or contraindication to blueberry products or study procedures
- Unwilling or unable to comply with study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 week
Participants collect stool and 24-hour urine samples at home, complete dietary recalls, and follow a low-polyphenol diet for three days prior to the test visit.
Home sample collections and dietary recalls
Duration - 1 day
Participants consume a standardized blueberry beverage after an overnight fast. Serial blood samples are collected over 8 hours, and standardized meals are provided. Participants initiate 24-hour urine collection and receive a stool collection kit for post-visit sampling.
1 visit (in-person) with multiple blood draws over 8 hours
Duration - 1 day
Participants return approximately 24 hours after blueberry consumption for a fasting blood draw and to return urine and stool samples.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Colorado State University; Food and Nutrition Clinical Research Laboratory; Gifford Building Room 216; 502 West Lake Street, Fort Collins, CO 80523
Fort Collins, Colorado, United States, 80523
Actively Recruiting
Research Team
T
Tiffany Weir, PhD
J
Jenny Whittington, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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