Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
ID05817305

Efficacy of an Exercise-based Secondary Prevention Program in Patients With Stable Cardiovascular Disease

Led by Università degli Studi di Ferrara · Updated on 2025-04-10

5000

Participants Needed

1

Research Sites

887 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the long-term effects of a personalized physical activity program on exercise capacity and quality of life in patients with stable cardiovascular disease. This observational registry aims to assess the value of cardiovascular function measured by a walking test (1km Treadmill Walking Test) in predicting survival, hospitalizations, and healthcare costs. The program integrates clinical, socio-economic, and behavioral factors along with psychological support and risk factor control to improve patient outcomes. Participants undergo sessions where physical measurements and medical history are recorded, and their cardiorespiratory fitness is assessed using a submaximal treadmill walking test adapted to their abilities. Based on test results, patients receive guidance on performing a home training program involving moderate-intensity aerobic activity for 30 to 60 minutes, 3 to 4 days per week, with encouragement to adopt a more active lifestyle at home and work. The study also provides health education and motivational counseling to support risk factor management and maintain active living. During the study, researchers collect data on weight, height, body mass index, blood pressure, cardiometabolic risk factors, medication use, and physical activity habits through questionnaires. Mortality, hospitalizations, peak oxygen uptake, and leisure-time physical activity levels are monitored for up to 12 years after enrollment. All participants provide informed consent and are followed long-term to evaluate the effects of the exercise program on their health and quality of life.

CONDITIONS

Brief Title

Integrating Exercise Into Lifestyle of Cardiac Outpatients

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 years or older
  • History of one or more previous cardiovascular events
  • Stable cardiovascular disease status
  • Ability to perform submaximal treadmill walking test or adapted test
Not Eligible

You will not qualify if you...

  • Ejection fraction less than 30%
  • Chronic heart failure classified as NYHA III or IV
  • Severe aortic or mitral valve disease
  • Severe physical or cognitive impairments
  • Exercise-induced complex arrhythmias

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Monitoring

Duration - Up to 12 years

Participants undergo medical history and functional evaluations during each session. Physical parameters such as weight, height, body mass index, blood pressure, cardiometabolic risk factors, and drug therapy are recorded. Participants complete a submaximal treadmill walking test to assess cardiorespiratory fitness. Based on test results, participants receive guidance for a home training program and are encouraged to adopt a more active lifestyle.

Regular sessions as part of the observational registry

Trial Site Locations

Total: 1 location

1

Center for Exercise Science and Sport

Ferrara, Ferrara, Italy, 44123

Actively Recruiting

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Research Team

G

Giovanni Grazzi, Professor

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Peak oxygen uptake prediction from a moderate, perceptually regulated, 1-km treadmill walk in male cardiac patients.

Giorgio Chiaranda, Jonathan Myers, Gianni Mazzoni...

https://pubmed.ncbi.nlm.nih.gov/22936157

Outdoor Reproducibility of a 1-km Treadmill Walking Test to Predict Peak Oxygen Uptake in Cardiac Patients.

Giovanni Grazzi, Giorgio Chiaranda, Jonathan Myers...

https://pubmed.ncbi.nlm.nih.gov/28671933

A moderate 500-m treadmill walk for estimating peak oxygen uptake in men with NYHA class I-II heart failure and reduced left ventricular ejection fraction.

Gianni Mazzoni, Biagio Sassone, Giovanni Pasanisi...

https://pubmed.ncbi.nlm.nih.gov/29661150

500-meter and 1000-meter moderate walks equally assess cardiorespiratory fitness in male outpatients with cardiovascular diseases.

Gianni Mazzoni, Giorgio Chiaranda, Jonathan Myers...

https://pubmed.ncbi.nlm.nih.gov/28967238

Treadmill walking speed and survival prediction in men with cardiovascular disease: a 10-year follow-up study.

Giorgio Chiaranda, Eva Bernardi, Luciano Codecà...

https://pubmed.ncbi.nlm.nih.gov/24163203

Association between VO₂ peak estimated by a 1-km treadmill walk and mortality. A 10-year follow-up study in patients with cardiovascular disease.

Giovanni Grazzi, Jonathan Myers, Eva Bernardi...

https://pubmed.ncbi.nlm.nih.gov/24630380

Improved walking speed is associated with lower hospitalisation rates in patients in an exercise-based secondary prevention programme.

Giovanni Grazzi, Gianni Mazzoni, Jonathan Myers...

https://pubmed.ncbi.nlm.nih.gov/27390367