Human papillomavirus vaccine introduction--the first five years.
Lauri E Markowitz, Vivien Tsu, Shelley L Deeks...
https://pubmed.ncbi.nlm.nih.gov/23199957Actively Recruiting
Phase Not Applicable
Age: 10Years - 13Years
All Genders
Healthy Volunteers
ID06650956
Integrated Service Delivery to Improve Adolescent Health and HPV Vaccination in Lao PDR: a Quasi-Experimental Mixed-Methods Study
Led by Health Poverty Action · Updated on 2025-03-12
700
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
H
Health Poverty Action
Lead Sponsor
G
Gavi, The Vaccine Alliance
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to determine if combining HPV vaccination with adolescent health services improves HPV vaccine uptake among girls aged 10 to 13 in Laos. It also evaluates the effect of this combined approach on the use of other health services by both boys and girls in this age group. The study explores barriers, facilitators, costs, and perceptions related to integrating HPV vaccination with sexual and reproductive health education and services. The study compares two groups: one receiving an integrated intervention package and the other receiving standard HPV vaccination services. The integrated package includes a single dose of recombinant HPV quadrivalent vaccine given through schools, health facilities, and community outreach. It also offers comprehensive sexuality education sessions, individual counseling, and access to other health services. The comparison group receives the same HPV vaccine through routine school, health facility, and outreach programs without additional sexual and reproductive health education or counseling. Participants aged 10 to 13 will be assessed at the start, 3 months, and 7 months after the intervention begins. Researchers will measure HPV vaccination rates, changes in knowledge and attitudes about sexual and reproductive health, use of other adolescent health services, healthcare provider workload, and stakeholder perceptions. They will also evaluate the costs and cost-effectiveness of the integrated approach. The study lasts about 9 months and includes both in-school and out-of-school adolescents in selected districts.
CONDITIONS
Brief Title
Integration to Improve Adolescent Health and HPV Vaccination in Laos
Who Can Participate
Age: 10Years - 13Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Female aged 10 to 13 years for HPV vaccination and sexual and reproductive health education
- Male aged 10 to 13 years for sexual and reproductive health education
- Students aged 10 to 13 years in randomly selected schools with at least 100 students in target classes (year-5 primary, year 1, 2, and 3 secondary)
- Males and females aged 10 to 13 years who are out-of-school and live in 2 remote villages from each of four randomly selected health centers around the selected schools
You will not qualify if you...
- Males and females younger than 10 years or older than 13 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Integrated HPV Vaccination and Adolescent Health Services
Duration - Approximately 7 months
Participants receive an integrated service package combining HPV vaccination with sexual and reproductive health education, delivered through school-based programs, health facility services, and community outreach to adolescents aged 10 to 13 years.
Multiple visits through schools, health facilities, and community outreach over 7 months
Assessment Visits
Duration - 7 months
Participants complete assessments of HPV vaccination rates and knowledge, attitudes, and practices related to sexual and reproductive health at baseline, mid-intervention, and end-of-intervention timepoints.
3 visits (at Month 0, Month 3, and Month 7)
Trial Site Locations
Total: 1 location
1
Sing District, Luang Namtha Province
Muang Sing, Province, Laos
Actively Recruiting
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Research Team
K
Kongmany Chaleunvong, MD, PhD
V
Viengnakhone Vongxay, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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Published Research Related To This Trial
Promoting adolescent health through integrated human papillomavirus vaccination programs: The experience of Togo.
Danielle Engel, Abra Dela Jeanne Afeli, Christopher Morgan...
https://pubmed.ncbi.nlm.nih.gov/34844819Sexual and reproductive health literacy of school adolescents in Lao PDR.
Viengnakhone Vongxay, Femke Albers, Souksamone Thongmixay...
https://pubmed.ncbi.nlm.nih.gov/30650100Health system inequities in Lao People's Democratic Republic: Evidence from a nationally representative phone survey.
Amit Aryal, Emma Clarke-Deelder, Souksanh Phommalangsy...
https://pubmed.ncbi.nlm.nih.gov/38685885Accelerate progress-sexual and reproductive health and rights for all: report of the Guttmacher-Lancet Commission.
Ann M Starrs, Alex C Ezeh, Gary Barker...
https://pubmed.ncbi.nlm.nih.gov/29753597