Actively Recruiting
An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence
Led by University of Southern California · Updated on 2026-04-28
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the cells and biomarkers linked to aggressive behavior in head and neck cancer, focusing on Human papillomavirus (HPV) positive Oropharyngeal Squamous Cell Carcinoma (OPSCC) and its spread to lymph nodes. This observational study aims to profile cancer-associated fibroblasts at a detailed single-cell level to better understand cancer progression and recurrence. Participants will undergo photography, blood sample collection, tissue collection, and medical record review. These procedures help researchers gather comprehensive information about the cancer's characteristics without providing any specific treatment intervention. During the study, participants' samples and medical history will be analyzed, and outcomes such as overall survival and disease-free survival will be tracked for up to five years. The study involves no treatment administration, focusing solely on observation and data collection to understand the disease better.
CONDITIONS
Brief Title
An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence
Who Can Participate
Eligibility Criteria
You may qualify if you...
- New diagnosis of head and neck cancer
- No prior treatment for head and neck cancer
- Age 18 years or older
- Ability and willingness to sign informed consent
You will not qualify if you...
- Previous treatment of head and neck cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants undergo photography, blood sample collection, tissue collection, and medical record review as part of observational assessments.
Visits occur as needed during the observation period
Duration - Up to 5 years
Participants are monitored for overall survival and disease-free survival over the course of the study.
Follow-up visits occur periodically over up to 5 years
Trial Site Locations
Total: 1 location
1
USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Actively Recruiting
Research Team
S
Sandy Tran, MS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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