Actively Recruiting
Interest of High-speed Centrifugation for Measuring Anti-Xa Activity on Lipemic Plasma
Led by University Hospital, Strasbourg, France · Updated on 2025-10-01
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate a method to improve blood test accuracy for patients on anticoagulant treatments who have lipemic plasma, which means their blood samples contain high levels of fats that can interfere with lab measurements. The study focuses on anti-Xa activity, a key test used to monitor the effect of blood thinners, which can be distorted by fat interference. At present, the Hematology Laboratory at University Hospital, Strasbourg, France, has no alternative method to correct this issue. The study will assess how effective a high-speed centrifugation process, spinning plasma samples at 10,800g for 10 minutes, is at separating out the lipid fraction that causes interference. This will be tested using routine care samples artificially overloaded with lipids to mimic lipemia. The goal is to see if this centrifugation step allows accurate measurement of anti-Xa activity despite high fat levels. Participants provide samples as part of routine care while on anticoagulant therapy, and these samples will be analyzed after centrifugation. The primary outcome measured is whether the high-speed centrifugation effectively removes lipids within 10 minutes. This observational study does not involve altering patient treatment and aims to improve laboratory techniques for better patient monitoring.
CONDITIONS
Brief Title
Interest of High-speed Centrifugation for Measuring Anti-Xa Activity on Lipemic Plasma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (≥ 18 years)
- Patient anticoagulated with an anti-Xa (UFH, LMWH, fondaparinux, danaparoid, apixaban, rivaroxaban)
- Sample sent to the HUS Hematology Laboratory and analyzed for measurement of the anti-Xa activity of an anticoagulant as part of routine care
You will not qualify if you...
- Patient with a basal lipidemic sample
- Sample of insufficient volume
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 minutes
Participants provide plasma samples as part of routine care for measurement of anti-Xa activity.
1 visit (sample collection during routine care)
Duration - Up to 10 minutes
Participants' samples are monitored to evaluate the effectiveness of high-speed centrifugation in separating lipid fractions.
No additional visits required
Trial Site Locations
Total: 1 location
1
Laboratoire d'Hématologie - Unité d'Hémostase - CHU de Strasbourg - France
Strasbourg, France, 67091
Actively Recruiting
Research Team
A
Agathe HERB, PharmD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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