Evaluating High-Speed Centrifugation to Improve Anti-Xa Activity Testing in Adults with Lipemic Plasma

What this Trial Is About

This research aims to evaluate a method to improve blood test accuracy for patients on anticoagulant treatments who have lipemic plasma, which means their blood samples contain high levels of fats that can interfere with lab measurements. The study focuses on anti-Xa activity, a key test used to monitor the effect of blood thinners, which can be distorted by fat interference. At present, the Hematology Laboratory at University Hospital, Strasbourg, France, has no alternative method to correct this issue. The study will assess how effective a high-speed centrifugation process, spinning plasma samples at 10,800g for 10 minutes, is at separating out the lipid fraction that causes interference. This will be tested using routine care samples artificially overloaded with lipids to mimic lipemia. The goal is to see if this centrifugation step allows accurate measurement of anti-Xa activity despite high fat levels. Participants provide samples as part of routine care while on anticoagulant therapy, and these samples will be analyzed after centrifugation. The primary outcome measured is whether the high-speed centrifugation effectively removes lipids within 10 minutes. This observational study does not involve altering patient treatment and aims to improve laboratory techniques for better patient monitoring.

Interest of High-speed Centrifugation for Measuring Anti-Xa Activity on Lipemic Plasma