Comparing How Three Broccoli Extract Supplements Are Absorbed and Processed in Healthy Adults Aged 18 to 60

What this Trial Is About

This research aims to compare how much glucoraphanin and sulforaphane from three different broccoli extract supplements are absorbed into the body and excreted in urine. The study involves generally healthy adults aged 18 to 60 years who do not smoke or are not pregnant or lactating. These compounds, naturally found in cruciferous vegetables, are thought to have health benefits including potential cancer prevention. Participants will consume three different versions of broccoli extract supplements, with glucoraphanin amounts ranging from 35 to 70 mg. The supplements include Avmacol Extra Strength tablets and chewable wafers. Each participant will complete three separate 24-hour study cycles, ingesting one of the supplements during each cycle. During each study cycle, participants will provide blood and urine samples over 24 hours at specified time points to measure glucoraphanin, sulforaphane, and their metabolites. They will also follow diet restrictions, avoiding cruciferous vegetables and certain supplements for one week prior to and during each cycle. Researchers will monitor how these compounds are absorbed and excreted to understand their bioavailability.

Investigating the Bioavailability of Broccoli Extract Supplements