Radiological and Audiological Correlation in Otosclerosis: a Prospective Case-Control Study Evaluating Temporal Bone CT, Bone Mineral Density, and Hearing Loss

What this Trial Is About

Researchers are studying adults diagnosed with otosclerosis to understand how findings from temporal bone CT scans relate to bone mineral density (BMD) and hearing ability. The study compares patients with otosclerosis to a control group without the condition to explore links between CT scan density, hearing loss severity, and levels of bone metabolism markers like vitamin D. This observational case-control study aims to improve diagnosis and prognosis for otosclerosis by combining imaging, bone health, and hearing data. Participants include adults diagnosed with otosclerosis who have had or will have surgical treatment such as stapedectomy or stapedotomy. Their high-resolution CT scans and bone metabolism markers will be analyzed. The control group consists of individuals without otosclerosis who have undergone temporal bone CT for other reasons and have no history of conductive or mixed hearing loss. Both groups will have bone mineral density and vitamin D levels assessed. During the study, participants will undergo bone mineral density tests using dual-energy X-ray absorptiometry (DEXA), serum vitamin D measurements, and audiological assessments including pure tone audiometry and speech discrimination tests. Researchers will measure CT scan density, hearing thresholds, air-bone gap, bone density, and vitamin D levels before surgery or at baseline. These assessments will help clarify relationships between imaging findings, hearing loss severity, and bone metabolism in otosclerosis.

Investigating the Relationship Between Temporal Bone CT, Bone Density, and Hearing Loss in Otosclerosis Patients