Actively Recruiting
Investigating the Relationship Between Temporal Bone CT, Bone Density, and Hearing Loss in Otosclerosis Patients
Led by İbrahim Emir Yeşil · Updated on 2025-02-20
86
Participants Needed
1
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational case-control study is to evaluate the relationship between temporal bone computed tomography (CT) findings, bone mineral density (BMD), and audiological parameters in adults diagnosed with otosclerosis. The main questions it aims to answer are: Is there a correlation between temporal bone CT density values and the severity of hearing loss in otosclerosis? Do bone mineral density and serum vitamin D levels differ between otosclerosis patients and individuals without otosclerosis? Researchers will compare patients diagnosed with otosclerosis to a control group without otosclerosis to determine if CT-based density variations are associated with disease severity and systemic bone metabolism markers. Participants who have already had a temporal bone CT scan as part of their routine clinical evaluation will undergo: Bone mineral density (BMD) assessment via dual-energy X-ray absorptiometry (DEXA) Serum vitamin D level measurement Audiological testing, including pure tone audiometry and speech discrimination tests This study aims to improve the diagnostic and prognostic understanding of otosclerosis by integrating imaging, metabolic, and audiological data.
CONDITIONS
Official Title
Investigating the Relationship Between Temporal Bone CT, Bone Density, and Hearing Loss in Otosclerosis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults diagnosed with otosclerosis based on audiological and clinical assessment
- Patients with available high-resolution CT scans and audiological data
- Individuals who have undergone stapedectomy or stapedotomy surgery
- Availability of bone mineral density and serum vitamin D data
- Patients without otosclerosis but with temporal CT imaging for other indications
- No history of conductive or mixed hearing loss (for control group)
- Availability of bone mineral density and serum vitamin D data (for control group)
You will not qualify if you...
- History of primary metabolic bone diseases such as osteoporosis or Paget's disease
- Use of medications affecting bone metabolism including bisphosphonates or corticosteroids
- History of chronic otitis media or prior ear surgeries
- Patients who received head and neck radiotherapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hacettepe University Hospitals
Ankara, Turkey (Türkiye), 06560
Actively Recruiting
Research Team
İ
İbrahim Emir Yeşil, MD
CONTACT
G
Gamze Atay, Assos Prof
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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