Actively Recruiting

Age: 20Years - 40Years
All Genders
Healthy Volunteers
ID07435935

Investigation of Postural Stability and Load-Sensitive Neuromuscular Control Mechanisms in Vitamin D Deficiency

Led by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Updated on 2026-05-27

24

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the link between vitamin D deficiency, postural stability, and neuromuscular control in adults aged 20 to 40 years. This observational study compares individuals with vitamin D deficiency to healthy controls to better understand how vitamin D status affects neuromuscular responses and balance. Participants are divided into two groups based on routine clinical test results for vitamin D levels. Those with vitamin D deficiency and those with normal vitamin D status both undergo a single session of non-invasive assessments. These include surface electromyography to measure muscle activity and tests of postural stability during various standing tasks, including single-leg and double-leg stance with and without vibration stimulation. During the single assessment session, researchers will record muscle activation and postural stability parameters under different conditions. They will analyze neuromuscular reflexes and how loading and vibration influence balance. The study aims to provide insights for future rehabilitation and balance training strategies. Participation involves no invasive procedures, medications, or additional blood tests, and results from prior routine labs are used to determine vitamin D status.

CONDITIONS

Brief Title

Bone Myoregulation Reflex and Postural Control in Vitamin D Deficiency

Who Can Participate

Age: 20Years - 40Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 20 to 40 years
  • Ability to provide written informed consent
  • Vitamin D deficiency group: serum 25-hydroxyvitamin D level <10 ng/mL measured within the last 3 months
  • Healthy control group: normal vitamin D status based on routine clinical testing within the last 3 months
  • No use of vitamin D or calcium supplementation within the last 3 months
Not Eligible

You will not qualify if you...

  • Known metabolic bone disease other than vitamin D deficiency
  • Neurological disorder (central or peripheral) or neuromuscular disease
  • History of lower-limb surgery, fracture, or prosthesis affecting standing balance
  • Vestibular disorder
  • BMI >30 kg/m2
  • Active malignancy
  • Severe psychiatric disorder
  • Skin condition preventing placement of surface EMG electrodes

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person) to confirm eligibility based on recent vitamin D laboratory results.

Diagnostic Evaluation

Duration - Single session

Participants undergo a standardized assessment protocol including non-invasive postural stability and surface electromyography measurements during standing tasks under various conditions.

1 assessment visit (in-person) involving muscle activity recordings and postural stability tests.

Long-term Monitoring

Duration - No additional visits; data analysis period only

Participants' neuromuscular and postural control data are observed and analyzed following the single assessment session.

No additional visits required.

Trial Site Locations

Total: 1 location

1

Istanbul Physical Medicine and Rehabilitation Training and Research Hospital

Istanbul, Turkey (Türkiye), 34186

Actively Recruiting

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Research Team

S

Selim Sezikli, MD

I

Ilhan Karacan, Prof.

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial