Comparing Ketamine and Dexmedetomidine Added to Bupivacaine for Pain and Blood Pressure Control During Supratentorial Brain Tumor Surgery

What this Trial Is About

Researchers are comparing the effects of ketamine and dexmedetomidine, both combined with bupivacaine, as adjuvants in scalp blocks for adults undergoing supratentorial brain tumor surgeries. The study aims to assess which combination better controls pain, opioid use, and blood pressure during and after surgery. This randomized, double-blind, controlled trial includes patients aged 20 to 60 with specific health status undergoing tumor excision in the supine position. Participants are randomly assigned to receive either a scalp block with bupivacaine and ketamine or bupivacaine and dexmedetomidine. The scalp block involves injecting local anesthetic around specific nerves on both sides of the scalp using a 23G needle after anesthesia induction. The study carefully monitors heart rate and blood pressure at multiple points during and after surgery, managing any deviations with medications as needed. During the study, participants will have pain assessed using a Numerical Rating Scale up to 24 hours after surgery. Researchers will record opioid consumption, time to first analgesic request, and any side effects like nausea or vomiting. Standard anesthesia and recovery protocols are followed, and detailed post-operative monitoring ensures safety and data collection. The total participation includes pre-surgery, surgery, and a 24-hour post-operative observation period.

Ketamine Versus Dexmedetomidine as an Adjuvant in Scalp Block in Supratentorial Brain Tumor Excision Surgeries