Actively Recruiting
Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study
Led by Indiana University · Updated on 2026-05-06
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
I
Indiana University
Lead Sponsor
A
Alzheimer's Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of combining computerized cognitive training with Tai Chi- Qi Gong exercise in people diagnosed with Early-Onset Alzheimer's Disease (EOAD). This study aims to gather preliminary data on whether this lifestyle intervention can improve thinking skills, daily functioning, and mood. The study also explores how individual characteristics might influence the benefits from the training. Participants will be randomly assigned to one of two groups for 14 weeks: one group will receive cognitive training using the BrainHQ mobile app alongside Tai Chi- Qi Gong exercise sessions, while the other group will use BrainHQ's brain games and perform stretching exercises. The cognitive training involves about 45 minutes per session, 4 to 5 times per week, and the Tai Chi or stretching sessions occur twice per week for around 30 minutes each. During the study, participants will undergo cognitive, functional, and mood assessments before the intervention, immediately after the 14-week intervention, and again 6 months later. These evaluations include computerized memory and executive function tests, self-reported questionnaires on cognition, depression, quality of life, stress, and social support. The study uses remote assessments and monitors participants' progress over several months to understand the short- and long-term effects of the lifestyle interventions.
CONDITIONS
Brief Title
Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Enrolled in the Longitudinal Early-Onset AD Study (LEADS) and classified as amyloid-positive Early Onset Alzheimer's Disease
- Aged between 40 and 64 years at enrollment into LEADS
- Fluent in English
- In good general health without other neurological disorders
- Have a knowledgeable informant
- Clinical Dementia Rating scale of 0.5 to 1.0 at LEADS enrollment
- Sufficient vision, hearing, comprehension, and manual skills to participate in testing and training
You will not qualify if you...
- Access to the internet for less than 4 hours per week
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 remote baseline visit
Duration - 14 weeks
Participants complete 14 weeks of lifestyle interventions consisting of either Cognitive Training combined with Tai Chi- Qi Gong exercise or Brain Games combined with stretching exercises.
Remote training sessions 4 to 5 times per week for cognitive devices and 2 times per week for behavioral exercises
Duration - 6 months post-treatment
Participants undergo assessments immediately after treatment and again at 6 months post-treatment to evaluate cognition, functioning, mood, and quality of life.
2 remote follow-up visits
Trial Site Locations
Total: 1 location
1
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
D
Dustin B Hammers, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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