First Al Minya

Researchers are studying the outcomes of two different revascularization treatments for children aged 7 to 13 with necrotic immature permanent maxillary incisors that show no symptoms. The trial aims to compare the clinical and radiographic results over 24 months following either a single-visit or multiple-visit protocol. This trial is a randomized clinical study led by Minia University to determine how these approaches affect healing and tooth health. Participants will receive either a single-visit revascularization procedure or a multiple-visit revascularization procedure. Each treatment protocol is designed to restore the affected tooth without surgery by encouraging natural healing. The study will observe and compare these two methods over a 24-month period to evaluate their effectiveness and outcomes. During the study, participants will be monitored for any pain experienced after treatment, with assessments continuing from enrollment through the full 24 months. Clinical and radiographic examinations will be carried out to evaluate healing progress and tooth condition. The trial includes regular follow-ups to track changes and ensure patient safety throughout the study duration.

Researchers are evaluating a newer technique to manage a complication called Descemets Membrane Detachment that can occur after cataract surgery. This study aims to measure how effective this method is in improving the condition by comparing two different approaches. The trial is interventional and sponsored by Minia University, focusing on patients aged 50 to 70 years who develop this complication within the first week after their surgery. Participants are randomly assigned to one of two groups. One group receives a direct injection of air inside the eyes anterior chamber, while the other group undergoes a procedure called anterior chamber deflation before receiving the air injection. This comparison is designed to see which method better helps the membrane reattach. During the study, researchers will monitor participants over a period of one week to assess the rate of complete anatomical reduction of the membrane detachment using imaging techniques. They will also track the time it takes for the membrane to fully reattach over one month. Participants will undergo eye examinations and imaging to measure outcomes and ensure safety throughout the trial, which is expected to complete by February 2026.

Researchers are evaluating the potential protective effect of Alpha-Lipoic Acid ALA against kidney damage caused by cisplatin chemotherapy in patients with solid tumors. This proof-of-concept, randomized, controlled, open-label clinical trial aims to assess changes in kidney function when ALA is added to standard preventive care during cisplatin treatment. The study is sponsored by Minia University and focuses on monitoring kidney health in oncology patients receiving cisplatin-based regimens. Participants are randomly assigned to one of two groups. Both groups receive standard preventive measures such as hydration, antiemetics, and mineral supplementation. The experimental group also takes oral Alpha-Lipoic Acid twice daily, starting two days before the first cisplatin dose and continuing throughout each chemotherapy cycle, for up to four cycles. The control group receives only standard preventive care alongside their chemotherapy. During the study, researchers monitor kidney function weekly for up to six weeks, assessing serum creatinine and creatinine clearance levels. They also evaluate patients quality of life and track occurrences of acute kidney injury, as well as any cisplatin dose changes due to kidney issues. Participants are followed closely throughout the treatment period to gather data on kidney health and safety outcomes related to the addition of ALA.

This research aims to identify and measure independent risk factors for anastomotic leakage AL, a serious complication following colorectal surgery, with rates ranging from 2% to 30%. The study will assess ALs incidence and its impact on patient outcomes, using criteria from the International Study Group of Rectal Cancer. Approximately 430 patients undergoing colorectal resection with anastomosis will be enrolled over one year in a single-center, prospective observational study to reduce variability. Participants will undergo elective or emergency colorectal surgery with primary anastomosis, including ileocolic, colocolic, colorectal, or coloanal types. The study will monitor risk factors before, during, and after surgery, including demographic data, comorbidities, surgical details, and postoperative management. AL will be defined and graded by severity from mild without treatment to severe requiring reoperation. The study will also analyze inflammatory markers in serum and drain fluid to detect leaks early. During the study, researchers will collect data from medical records, surgical notes, and follow-up visits. They will evaluate outcomes such as AL incidence within 30 days post-surgery, severity, reoperation, readmission, hospital stay length, mortality, and the need for permanent stoma within 90 days. Statistical analysis will develop and validate predictive models for AL risk. The study follows ethical standards and requires informed consent from participants.

Laryngomalacia is the most common congenital laryngeal anomaly in infants and is often linked to feeding difficulties and aspiration. This randomized controlled trial evaluates whether proton pump inhibitor PPI therapy can reduce the incidence of aspiration in children aged 6 months to 5 years with laryngomalacia. The study aims to provide evidence to improve management and reduce aspiration-related complications. Participants will be randomly assigned to one of two groups one receiving PPI therapy along with vitamin D supplementation and feeding instructions, and the other receiving vitamin D supplementation and feeding instructions only as standard care. Clinical and swallowing evaluations will be conducted at the start and during follow-up to compare aspiration rates and swallowing outcomes between the groups. During the study, children will undergo clinical assessments and swallowing tests at baseline and follow-up visits. Researchers will measure the incidence of aspiration over two months to determine the effect of adding PPI therapy. The study includes safety monitoring and lasts until the completion date, with participant involvement spanning the treatment and follow-up periods to assess outcomes.

This research aims to evaluate the effects of adding magnesium sulfate to atracurium alongside a local anesthetic mixture on the eye and eyelid movement during cataract surgery using the peribulbar technique. The study focuses on measuring how quickly akinesia loss of movement begins and how long it lasts. Regional anesthesia, especially peribulbar block, is preferred for eye surgery because it is safe, affordable, and effective, with fewer serious complications compared to retrobulbar blocks. Participants receive one of three treatments during cataract surgery a control group with a local anesthetic mixture alone, a group receiving atracurium with the anesthetic, or a group given atracurium plus magnesium sulfate with the anesthetic. Each group undergoes a peribulbar block with detailed mixtures of bupivacaine, lidocaine, hyaluronidase, and saline, with specific doses of atracurium and magnesium sulfate where applicable. During the study, patients undergoing elective cataract surgery are monitored for the quality and success of the anesthesia block. Researchers observe the onset and duration of akinesia in the eye and eyelid. Safety and effectiveness are assessed through clinical evaluation during surgery. The total participant age range is 20 to 80 years, including both sexes and patients with ASA physical status I and II. The study duration and follow-up details are aligned with the surgical procedure timeline.

Researchers are investigating ureteral stent-related symptoms in adults who need temporary stenting after unilateral ureteroscopy or retrograde intrarenal surgery for urinary stones. The study compares a newer ComfiJ ureteral stent with a conventional double-J ureteral stent to understand which stent causes fewer urinary symptoms and related issues. The trial is randomized and multicenter, focusing on patient comfort and quality of life after surgery. Participants will be randomly assigned during surgery to receive either a ComfiJ or conventional double-J ureteral stent if short-term postoperative stenting is needed. The stents are planned to remain in place for about 14 days before removal. The study uses a double-blind design where patients and outcome assessors do not know which stent was used, while surgeons are aware during insertion. Throughout the study, participants will complete the Arabic Ureteral Stent Symptom Questionnaire to assess urinary symptoms, along with pain scores and records of analgesic use, emergency visits, and complications. Researchers will also monitor stent migration, ease of insertion and removal, and patient satisfaction. The main outcome is the urinary symptoms score on day 14 before stent removal. Follow-up assessments occur up to postoperative day 14, and the study is scheduled to end in May 2027.

This clinical trial focuses on adults aged 20 to 60 who require immediate implant placement in the upper front teeth area. Researchers are evaluating whether the socket-shield technique can better preserve bone density, bone levels, and the health of the tissues around the implant compared to the conventional immediate implant method. The study aims to answer key questions about bone preservation and soft tissue health after implant placement. Participants receive immediate implant placement using either the conventional technique or the socket-shield technique following tooth extraction. They are divided into two groups one group receives the implant by the conventional method, while the other group receives the socket-shield method. The study includes clinical and radiographic exams, such as cone beam computed tomography CBCT, to monitor outcomes. During the 9-month follow-up period, participants attend regular visits for clinical and radiographic evaluations to assess bone density, bone levels, probing depth, gingival health, plaque levels, gingival thickness, and keratinized tissue width. Researchers track implant stability and peri-implant tissue health through these assessments to understand the healing process and overall outcomes of each technique.

Post-dural puncture headache PDPH is a common and painful complication experienced by pregnant patients undergoing cesarean sections with spinal anesthesia. This trial evaluates and compares treatments for acute PDPH using nebulized neostigmineatropine versus lidocaine, alongside standard medical care. The purpose is to find effective treatments to relieve this headache, which occurs due to cerebrospinal fluid leakage causing pain and cerebral blood vessel changes. Participants are randomly assigned to one of three groups a control group receiving saline nebulization twice daily for three days with conventional care a neostigmineatropine group receiving nebulized doses twice daily plus conventional care or a lidocaine group receiving nebulized lidocaine twice daily along with conventional care. Conventional care includes bed rest, hydration through lactated Ringer solution infusion, paracetamol every 6 hours, and diclofenac suppositories as routine post-operative pain management. During the study, participants will be monitored for headache severity using the Visual Analog Scale at multiple time points up to 120 hours post-intervention. Additional assessments include headache classification, need for epidural blood patch, and neurological and procedural complications. Transcranial Doppler ultrasound scans will be performed at different intervals to observe cerebral blood flow. The study is double-blinded and aims to complete by early 2027, with participants involved for several days of treatment and follow-up.

This trial investigates the use of Concerned Growth Factor compared to Mineral Trioxide Aggregate in treating mature permanent molars in children aged 9 to 16 years who have symptomatic irreversible pulpitis. The study aims to evaluate these two treatment options in managing this dental condition to determine their clinical and radiographic success over 12 months. Participants will receive either the Concerned Growth Factor procedure or Mineral Trioxide Aggregate treatment for their affected molars. The study is an 18-month randomized control trial led by Minia University, focusing on children with mature permanent molars diagnosed with irreversible pulpitis. Throughout the 12-month follow-up, researchers will assess clinical outcomes using methods like a visual analogue scale, electrical pulp testing, hot and cold sensibility tests, and percussion tests. Radiographic evaluations will also be performed to measure the success of the treatments. Participants will be monitored for any changes or improvements in their dental health during this period.