Manfalut

Researchers are evaluating the potential heart-protective effects of pentoxifylline in breast cancer patients receiving doxorubicin chemotherapy. This phase 2 clinical trial aims to compare changes in heart function, specifically ejection fraction, and blood markers related to heart stress and inflammation between patients receiving standard chemotherapy alone and those receiving chemotherapy plus pentoxifylline. The study addresses concerns about heart damage caused by doxorubicin treatment in breast cancer care. Participants will be randomly assigned to one of two groups one group will receive standard chemotherapy alone, and the other will receive standard chemotherapy combined with pentoxifylline at a dose of 400 mg taken orally three times daily with meals. The study lasts for at least three months during which the effects of pentoxifylline on chemotherapy-induced heart damage will be monitored. During the study, participants will undergo assessments including heart function tests to measure ejection fraction and blood tests to check levels of NT-pro-BNP and TNF-, which are indicators of heart stress and inflammation. These evaluations occur over a three-month period to track changes related to the treatments. Safety and overall health will be monitored throughout to understand the impact of adding pentoxifylline to chemotherapy in breast cancer patients.

This research aims to compare the safety and effectiveness of two drugs, dexmedetomidine and dexamethasone, as additions to bupivacaine for pain control in patients undergoing total thyroidectomy. The study focuses on patients who experience pain after thyroid surgery, which can delay hospital discharge and impact both patients and healthcare providers. It is a phase four, randomized, double-blind clinical trial involving 60 patients. Participants are divided into two groups one group receives a bilateral intermediate cervical plexus block with bupivacaine plus dexmedetomidine, and the other group receives bupivacaine plus dexamethasone. The nerve block is guided by ultrasound to provide pain relief during and after surgery. Both treatments are administered under general anesthesia. Throughout the study, researchers will measure pain levels using the Numeric Pain Rating Scale 24 hours after surgery, tracking median, range, mean, and standard deviation scores. They will also monitor drug-related side effects during this same period. The study is designed to evaluate pain relief effectiveness and safety of these adjuvants to improve recovery after thyroidectomy. Participation spans the surgery and immediate postoperative period with monitoring focused on the first 24 hours after operation.

This research aims to evaluate the effect of a digital interactive classroom using the Thinqi platform on the knowledge retention and engagement of undergraduate critical care nursing students. The study compares this digital approach with conventional training methods to understand how digital tools can enhance learning in nursing education. Participants will be divided into two groups one group of 50 nursing students will use the Thinqi platform for training on ECG interpretation, which offers interactive features like live chat, multimedia elements, discussion forums, and digital libraries. The other group of 50 students will receive conventional training through handout exercises. The study uses a randomized design with a single masking approach. Students will be assessed on their knowledge retention of ECG interpretation at baseline and one month after a quiz. Engagement and learning progress will be monitored using reports and statistics from the platform and conventional exercises. The study involves nursing students registered in the second academic level and enrolled in the Emergency Nursing Course, with participation expected to last at least one month after the training.

This research aims to evaluate the effect of the Heart Math intervention program on stress levels, emotional vitality, and sense of coherence among nurses working in intensive care units. The study focuses on how this behavioral program may influence these important aspects of wellbeing in a high-stress healthcare environment. The intervention consists of seven sessions delivered twice weekly, each lasting about 45 to 60 minutes. Each session introduces specific techniques such as heart coherence, heart-focused breathing, quick coherence, heart lock-in, freeze frame, attitude breathing, and coherence communication. Nurses participating will either receive this Heart Math program or no intervention as part of a randomized, single-blind study design. Participants will be monitored over two months, with assessments including resilience scales, personal and organizational quality evaluations, and measures of sense of coherence. The research involves tracking individual progress through personal practice logs and questionnaires to evaluate the impact of the intervention on stress and emotional health during the study period.

This research aims to evaluate the impact of cough augmentation techniques on the success of weaning from mechanical ventilation in critically ill adult patients. These patients often have weakened cough strength due to factors such as mechanical ventilation, neuromuscular weakness, sedation, or respiratory muscle dysfunction, which can impair airway clearance and breathing support removal. The study compares two groups one receiving specialized cough augmentation techniques including manual assisted cough, lung volume recruitment maneuvers, and mechanical insufflation-exsufflation, and the other receiving routine care. Lung volume recruitment involves increasing end-inspiratory volume using pressure-controlled ventilation to improve cough effectiveness. These interventions are provided under physician supervision during the treatment period. Participants will be monitored to assess weaning success within 7 days. The study includes assessments of breathing function and airway clearance, with ongoing evaluation of patient responses. Researchers will track clinical outcomes related to breathing support removal, with safety and progress monitored throughout the study duration, which runs from July to November 2026.

This trial investigates how two different regional anesthesia techniques compare in managing pain after supraumbilical surgery, a common procedure for hernia repair known to cause moderate to severe postoperative pain. The study focuses on the erector spinae plane block ESPB and the rectus sheath block RSB, assessing their effectiveness in reducing the need for opioid pain medicines and their impact on patient recovery and side effects. Participants will be randomly assigned to one of two groups. One group will receive general anesthesia plus a postoperative bilateral ultrasound-guided ESPB, while the other group will receive general anesthesia plus a postoperative bilateral ultrasound-guided RSB. Both procedures target specific nerve areas to provide pain relief after surgery. This is a double-blind, randomized trial including 60 adult patients undergoing elective supraumbilical surgery. During the study, participants pain levels, time until first request for additional pain relief, total amount of rescue analgesic used, and any postoperative complications will be closely monitored for 24 hours after the nerve block. Researchers will use pain rating scales and measure medication use to evaluate outcomes. Safety and side effects will also be recorded, with the total participation lasting through the immediate postoperative period and follow-up within the first day after surgery.

Researchers are comparing the safety and effectiveness of nylon polyamide versus polyurethane epidural catheters in patients undergoing major orthopedic surgery using continuous epidural anesthesia. This study addresses common complications associated with epidural catheters such as improper placement, nerve irritation, catheter kinking, hematoma, or breakage during removal. The trial is a prospective, randomized, double-blind clinical study involving 60 patients. Participants are randomly assigned to one of two groups one group receives continuous epidural anesthesia with a nylon catheter, while the other group receives a polyurethane catheter. Each group includes 30 patients. The study evaluates the time required for catheter insertion, anchoring, and removal, as well as the rate of catheter-related complications. The interventions take place during the course of major orthopedic surgery. Throughout the study, researchers measure the time taken for key procedures involving the epidural catheter, including insertion and removal, and monitor for any catheter-related complications. These measurements occur shortly after identifying the epidural space, after needle removal, and at the end of the operation. The trial follows patients aged 21 to 60 years with specific health criteria, ensuring close monitoring of anesthesia performance and safety outcomes.

Researchers are comparing the safety and effectiveness of two oral medications, atenolol and metoprolol, used as premedications for controlled hypotensive anesthesia in patients undergoing nasal surgeries. This phase four, prospective, randomized, double-blind clinical trial addresses the issue of mucosal bleeding, a common complication that can increase surgery time and blood loss during nasal operations. Participants are divided into two groups one receives oral atenolol 50 mg and the other oral metoprolol 100 mg as premedication. The study involves controlled hypotensive anesthesia during the nasal surgery procedure. The trial is conducted under rigorous conditions including quadruple masking and random allocation to ensure unbiased comparison. During the study, participants blood loss is measured five minutes after surgery to evaluate the primary outcome. The trial includes assessments of safety and efficacy throughout the procedure. The total participation period spans from premedication administration through surgery and immediate postoperative monitoring. The trial is sponsored by Damanhour Teaching Hospital and runs until January 2026.

This research aims to explore how different mechanical ventilation modes affect intra-abdominal pressure IAP, mechanical power MP, and gastric tube tolerance in adults who require mechanical ventilation in the intensive care unit ICU. The study focuses on three commonly used ventilation modes SIMV, BIPAP, and CPAP, investigating their impact on respiratory mechanics and overall body system functions. Participants are divided into three groups based on the ventilation mode used SIMV, CPAP, or BiPAP. Each group receives mechanical ventilation through the assigned mode while being monitored for the effects on intra-thoracic pressure and related physiological responses. The study observes the participants primarily on the first day of ventilation to assess IAP, mechanical power, and gastric tube tolerance. During the study, participants are monitored closely for the specified outcomes including intra-abdominal pressure, mechanical power, and gastric tube tolerance on day one. The assessments help understand how the ventilation mode influences these parameters. Participants are adults between 18 and 60 years old who require mechanical ventilation in the ICU. The study lasts from August 2026 to November 2026, with data collection and monitoring occurring during this period.

This research aims to compare two recent pain control techniques, Rhomboid intercostal block RIB and Retrolaminar block RLB, for managing pain after thoracoscopic sympathectomy in adults. The study focuses on understanding which method provides better postoperative pain relief and how they affect patient outcomes after this surgical procedure. Participants will be randomly divided into two groups of 30 each. One group will receive general anesthesia combined with an intraoperative ultrasound-guided Rhomboid intercostal block on the same side as the surgery, while the other group will receive general anesthesia with an intraoperative ultrasound-guided Retrolaminar block. Both procedures take place during the surgery. During the trial, researchers will monitor and compare the time until patients first request additional pain medication within 24 hours after surgery. They will also assess pain levels using a numeric rating scale and track the total amount of rescue pain medicine used. This double-blind trial involves detailed monitoring of pain relief and medication use during the first day after surgery to evaluate the effectiveness of each block method.