Manfalut

Researchers are studying the protective effects of pentoxifylline on heart function in women with breast cancer who are receiving doxorubicin chemotherapy. This phase 2 clinical trial aims to determine whether pentoxifylline can reduce heart damage caused by doxorubicin, focusing on changes in the heart's ejection fraction as the primary outcome. Secondary outcomes include changes in blood levels of NT-pro-BNP and TNF-alpha, which are markers related to heart stress and inflammation. Participants are divided into two groups: one receives standard chemotherapy alone, and the other receives chemotherapy combined with pentoxifylline at a dose of 400 mg taken orally three times daily with meals. The study involves random assignment to these groups to compare the effects of adding pentoxifylline on heart health during cancer treatment. During the study, participants will be monitored with echocardiograms to assess heart function and have blood tests to measure cardiac biomarkers. The main measurement is the change in ejection fraction after three months. Overall health and side effects will be tracked to evaluate the safety and impact of the treatments over the study period.

Many patients undergoing thyroidectomy experience postoperative pain, which can delay their discharge from the hospital and increase stress for both patients and healthcare providers. This research compares two drugs, dexmedetomidine and dexamethasone, used as additives to bupivacaine in a nerve block called the intermediate cervical plexus block. This block is applied with ultrasound guidance during total thyroidectomy performed under general anesthesia to improve pain relief. The trial is a phase four, randomized, double-blind study involving 60 patients. Participants are divided into two groups. One group receives bilateral intermediate cervical plexus blocks with bupivacaine plus dexmedetomidine, while the other group receives the block with bupivacaine plus dexamethasone. Dexmedetomidine is given at a dose of 50 mcg, and dexamethasone at 4 mg. Both treatments aim to extend the duration and effectiveness of the nerve block for managing pain after surgery. During the study, patients' pain levels are assessed 24 hours after surgery using the Numeric Pain Rating Scale, measuring median, range, mean, and standard deviation. Researchers monitor safety and efficacy throughout the process. The study focuses on adults aged 21 to 60 years with specific health criteria. The goal is to find which additive provides better pain control and safety for patients undergoing thyroidectomy.

This research aims to evaluate how using the Thinqi digital interactive classroom platform affects knowledge retention and engagement among undergraduate critical care nursing students. The study focuses on students enrolled in the Emergency Nursing Course, comparing digital learning methods to traditional approaches. Digital platforms like Thinqi offer tools for course management, assignments, discussion forums, live chats, multimedia content, and digital libraries to enhance learning experiences. Participants will be divided into two groups. One group will receive training on ECG interpretation using the Thinqi platform, which supports interactive and cooperative learning with multimedia elements. The other group will be trained through conventional handout exercises. This setup allows comparison of digital interactive learning versus handout-based training. During the study, researchers will measure students' knowledge retention at baseline and one month after the quiz. Engagement levels will also be assessed throughout the training. The study includes nursing students registered in the second academic level and lasts through their Emergency Nursing Course. Various reports, statistics, and interaction data from the Thinqi platform will help evaluate student achievement and participation.

This research aims to evaluate the impact of the Heart Math intervention program on stress levels, emotional vitality, and the sense of coherence among nurses working in intensive care units. The study focuses on how this program may influence these important psychological and emotional factors in a high-stress healthcare environment. The intervention consists of seven sessions conducted twice a week, each lasting about 45 to 60 minutes. The sessions cover topics such as understanding stress and heart coherence, teaching Heart-Focused Breathing and Quick Coherence techniques, anxiety assessment, and practicing various Heart Math methods including Heart Lock-In, Freeze Frame, Attitude Breathing, and Coherence Communication Techniques. Each session includes handouts to support learning and personal practice logs. Participants will be involved in attending these sessions and completing homework assignments related to the techniques taught. Researchers will assess resilience, personal and organizational quality, and sense of coherence over a two-month period. The study includes ongoing evaluation through questionnaires and personal practice logs to monitor changes and adherence to the intervention techniques.

Researchers are comparing two regional anesthesia techniques, the erector spinae plane block (ESPB) and the rectus sheath block (RSB), to evaluate their effectiveness in managing postoperative pain after supraumbilical surgery in adults. Supraumbilical hernia repair is common and often causes moderate to severe pain after surgery, leading to high opioid use with related side effects such as drowsiness and nausea. Regional blocks like ESPB and RSB aim to reduce opioid needs by providing targeted pain relief with fewer adverse effects. The trial involves 60 adult patients scheduled for elective supraumbilical surgery under general anesthesia. Participants are randomly assigned to two groups: one group receives bilateral ultrasound-guided ESPB after surgery, and the other group receives bilateral ultrasound-guided RSB postoperatively. Both techniques target nerves supplying the abdominal wall but differ in their specific areas of analgesia, with ESPB blocking both somatic and visceral nerves and RSB targeting anterior abdominal wall nerves. During the study, researchers will monitor the time until patients first request additional pain medication within 24 hours after the block. Patients’ pain levels and opioid use will be tracked to assess analgesic effectiveness. The study includes adult patients aged 21 to 60 years with good general health and excludes those with infections, mental status changes, pregnancy, allergies to study drugs, chronic pain, blood clotting issues, or severe liver or kidney disease. The trial aims to identify which block provides better pain control and patient outcomes after supraumbilical surgery.

Researchers are comparing the safety and effectiveness of nylon (polyamide) versus polyurethane epidural catheters in patients undergoing major orthopedic surgery with continuous epidural anesthesia. Epidural anesthesia is commonly used in orthopedic procedures, but catheter use can lead to complications such as intravascular or intrathecal placement, nerve irritation, paresthesia, kinking, hematoma, or catheter breakage during removal. This study is a prospective, randomized, double-blind clinical trial involving 60 patients. Participants are randomly assigned to two groups: one receiving the nylon epidural catheter and the other receiving the polyurethane epidural catheter. The study evaluates the insertion time of the catheters using the loss of resistance technique. The trial focuses on the comparison of these two catheter types during continuous epidural anesthesia for major orthopedic surgery. During the study, researchers measure the time required for epidural catheter insertion and monitor patients for any complications or catheter issues. The trial includes adults aged 21 to 60 who meet specific health criteria. Safety and catheter function are assessed throughout the procedure to determine differences between the two catheter types.

Researchers are evaluating the safety and effectiveness of oral atenolol compared to oral metoprolol as premedication for controlled low blood pressure anesthesia during nasal surgeries. This phase four randomized, double-blind clinical trial addresses the common problem of mucosal bleeding during nasal surgeries, which can obscure the surgical view, prolong operation time, and increase blood loss. The study involves 60 patients scheduled for nasal surgery under general anesthesia. Participants are randomly divided into two groups: one receives 50 mg of oral atenolol, and the other receives 100 mg of oral metoprolol. These medications are given before surgery to control blood pressure and reduce bleeding. The trial compares these two beta-blockers to assess their impact on surgical blood loss. Participants will be monitored closely during and after surgery, with researchers measuring blood loss five minutes after surgery ends. Safety and side effects will also be assessed. The study includes adult patients aged 21 to 50 years with good physical health status. The trial aims to provide insights into better premedication choices to manage bleeding risks during nasal surgeries.

Researchers are comparing two recent pain control methods, the Rhomboid Intercostal Block (RIB) and the Retrolaminar Block (RLB), to see which is more effective for managing pain after thoracoscopic sympathectomy, a surgery done through small incisions but known for causing severe postoperative pain. This study is a prospective, randomized, double-blind clinical trial involving adult patients with certain physical health status and body weight limits. Participants are randomly assigned into two groups of 30 each. One group receives general anesthesia combined with an ultrasound-guided RIB on the same side as the surgery, while the other group receives general anesthesia combined with an ultrasound-guided RLB on the same side. Both interventions are performed during the surgery. Throughout the study, researchers will monitor how long it takes after surgery for patients to first request additional pain medication within 24 hours. This measurement includes the average and variability of the time before needing postoperative rescue analgesics. The study includes adult patients aged 18 to 60 years with specific health criteria, and it aims to assess the impact of these blocks on patient outcomes following surgery.

Critically ill adults who have been intubated may face serious complications after the breathing tube is removed, such as swelling of the voice box (laryngeal edema), sudden tightening of the vocal cords (laryngospasm), and difficulty swallowing (dysphagia). These issues can delay full recovery after extubation. This research evaluates how using a clinical pathway—a planned approach to care—can help manage and reduce these post-extubation complications in adult patients. The study involves monitoring the pressure in the breathing tube cuff, suctioning the tube, and using techniques to help with coughing and swallowing, such as the Larson maneuver and rehabilitation exercises. Participants may also receive treatments like nebulized budesonide and intravenous methylprednisolone. These combined interventions are designed to support airway health and swallowing function in patients who were intubated and mechanically ventilated for less than two weeks. Participants will be adults aged 18 to 60 who have been intubated for the first time with a Glasgow coma scale between 13 and 15. Researchers will assess the prevention of laryngeal edema, laryngospasm, and swallowing difficulties within 72 hours after extubation. The study will carefully monitor these outcomes to determine how well the clinical pathway helps patients recover and avoid complications after removing the breathing tube.